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British Journal of Cancer logoLink to British Journal of Cancer
. 1973 Dec;28(6):589–591. doi: 10.1038/bjc.1973.190

Methotrexate in Liver and Bile after Intravenous Dosage in Man

P J Creaven, H H Hansen, D A Alford, L M Allen
PMCID: PMC2008933  PMID: 4783160

Abstract

Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [3H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bischoff K. B., Dedrick R. L., Zaharko D. S., Longstreth J. A. Methotrexate pharmacokinetics. J Pharm Sci. 1971 Aug;60(8):1128–1133. doi: 10.1002/jps.2600600803. [DOI] [PubMed] [Google Scholar]
  2. Bischoff K. B., Dedrick R. L., Zaharko D. S. Preliminary model for methotrexate pharmacokinetics. J Pharm Sci. 1970 Feb;59(2):149–154. doi: 10.1002/jps.2600590203. [DOI] [PubMed] [Google Scholar]
  3. Dedrick R. L., Zaharko D. S., Lutz R. J. Transport and binding of methotrexate in vivo. J Pharm Sci. 1973 Jun;62(6):882–890. doi: 10.1002/jps.2600620603. [DOI] [PubMed] [Google Scholar]
  4. Hall T. C., Roberts D., Kessel D. H. Methotrexate and folic reductase in human cancer. Eur J Cancer. 1966 Jun;2(2):135–142. doi: 10.1016/0014-2964(66)90006-5. [DOI] [PubMed] [Google Scholar]
  5. Henderson E. S., Adamson R. H., Oliverio V. T. The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man. Cancer Res. 1965 Aug;25(7):1018–1024. [PubMed] [Google Scholar]
  6. OSBORN M. J., FREEMAN M., HUENNEKENS F. M. Inhibition of dihydrofolic reductase by aminopterin and amethopterin. Proc Soc Exp Biol Med. 1958 Feb;97(2):429–431. doi: 10.3181/00379727-97-23764. [DOI] [PubMed] [Google Scholar]

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