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. 1973 Sep;28(3):238–244. doi: 10.1038/bjc.1973.143

Prevention of Murine Sarcoma Virus Oncogenesis in Offspring of Immunized Female Mice

L Chieco-Bianchi, D Collavo, G Biasi, A Colombatti
PMCID: PMC2008979  PMID: 4795530

Abstract

BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not. A reduced number of tumours was observed in 3 out of 14 MSV-M injected litters whose mothers had been previously exposed to the virus while nursing infected offspring. Sera from suckling mice born to and nursed by immunized mothers contained MSV-M neutralizing antibody as shown by an in vitro focus reduction assay. Cell-free extracts from mice which developed leukaemia after MSV-M inoculation were tested for oncogenic activity in 1-week old mice. Out of 6 extracts, 4 induced typical MSV-M tumours and 2 caused leukaemias.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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