Abstract
Groups of mice were exposed to various doses of ionizing radiation on one occasion. In two groups of animals the bladder carcinogens dibutylnitrosamine (DBNA) and 4-ethylsulphonyl-naphthalene-1-sulphonamide (ENS) were administered 48 hours after irradiation.
Post mortem and histopathological examinations failed to show any significant lesion in the bladder of animals subjected to radiation per se. Furthermore, radiation did not influence the latent period or incidence of bladder tumours induced by DBNA and ENS. However, radiation shortened the latent period of mammary tumours and, in some groups, increased the incidence of such lesions. When radiation was combined with the chemical carcinogens there was a marked reduction in the incidence of mammary tumours.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bertram J. S., Craig A. W. Induction of bladder tumours in mice with dibutylnitrosamine. Br J Cancer. 1970 Jun;24(2):352–359. doi: 10.1038/bjc.1970.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clayson D. B., Pringle J. A., Bonser G. M. 4-ethylsulphonylnaphthalene-1-sulphonamide: a new chemical for the study of bladder cancer in the mouse. Biochem Pharmacol. 1967 Apr;16(4):619–626. doi: 10.1016/0006-2952(67)90072-x. [DOI] [PubMed] [Google Scholar]
- DRUCKREY H., PREUSSMANN R., IVANKOVIC S., SCHMIDT C. H., MENNEL H. D., STAHL K. W. SELEKTIVE ERZEUGUNG VON BLASENKREBS AN RATTEN DURCH DIBUTYL- UND N-BUTYL-N-BUTANOL(4)-NITROSAMIN. Z Krebsforsch. 1964 Nov 2;66:280–290. [PubMed] [Google Scholar]
- Dzhioev F. K., Wood M., Cowen D. M., Campobasso O., Clayson D. B. Further investigations on the proliferative response of mouse bladder epithelium to 4-ethyl-sulphonylnaphthalene-1-sulphonamide. Br J Cancer. 1969 Dec;23(4):772–780. doi: 10.1038/bjc.1969.96. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wood M., Flaks A., Clayson D. B. The carcinogenic activity of dibutylnitrosamine in IF x C57 mice. Eur J Cancer. 1970 Oct;6(5):433–440. doi: 10.1016/0014-2964(70)90042-3. [DOI] [PubMed] [Google Scholar]