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. 1973 Sep;28(3):245–256. doi: 10.1038/bjc.1973.144

Cellular Reaction in Trophoblastic Tumours

C W Elston, K D Bagshawe
PMCID: PMC2008989  PMID: 4355270

Abstract

The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a “severe” cellular reaction than in those with a “mild” reaction to gestational choriocarcinoma. The pathological and clinical features of invasive moles showed no relationship with the cellular reaction to the tumour. The cellular reaction to trophoblastic teratomata was generally poor but there was a marked cellular reaction to the tumour of one patient who has enjoyed a sustained remission.

The relationship of cellular reaction and response to treatment with other histological and clinical features was examined. With the exception of a positive correlation between the degree of vascular invasion and response to treatment, none was found.

It is suggested that an infiltrate of mononuclear cells in gestational choriocarcinoma is probably a response to the presence of tumour antigens. The infiltrate favourably affects the response to chemotherapeutic agents, suggesting that it contributes to tumour cell death and it may be interpreted as an immunological response directed at tumour rejection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAGSHAWE K. D. TROPHOBLASTIC TUMOURS. CHEMOTHERAPY AND DEVELOPMENTS. Br Med J. 1963 Nov 23;2(5368):1303–1307. doi: 10.1136/bmj.2.5368.1303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARDAWIL W. A., TOY B. L. The natural history of choriocarcinoma: problems of immunity and spontaneous regression. Ann N Y Acad Sci. 1959 Aug 28;80:197–261. doi: 10.1111/j.1749-6632.1959.tb49205.x. [DOI] [PubMed] [Google Scholar]
  3. BLACK M. M., OPLER S. R., SPEER F. D. Microscopic structure of gastric carcinomas and their regional lymph nodes in relation to survival. Surg Gynecol Obstet. 1954 Jun;98(6):725–734. [PubMed] [Google Scholar]
  4. BLACK M. M., SPEER F. D., OPLER S. R. Structural representations of tumor-host relationships in mammary carcinoma; biologic and prognostic significance. Am J Clin Pathol. 1956 Mar;26(3):250–265. doi: 10.1093/ajcp/26.3.250. [DOI] [PubMed] [Google Scholar]
  5. BREYERE E. J. MATERNAL IMMUNOLOGIC TOLERANCE. Med Ann Dist Columbia. 1964 Mar;33:93–96. [PubMed] [Google Scholar]
  6. Bagshawe K. D. Gonadotrophin excretion, pelvic arteriography and treatment in post-molar trophoblastic disease. Proc R Soc Med. 1967 Mar;60(3):240–242. doi: 10.1177/003591576706000319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bagshawe K. D., Rawlins G., Pike M. C., Lawler S. D. ABO blood-groups in trophoblastic neoplasia. Lancet. 1971 Mar 20;1(7699):553–556. doi: 10.1016/s0140-6736(71)91159-7. [DOI] [PubMed] [Google Scholar]
  8. Bagshawe K. D. Tumour growth and anti-mitotic action. The role of spontaneous cell losses. Br J Cancer. 1968 Dec;22(4):698–713. doi: 10.1038/bjc.1968.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Beer A. E., Billingham R. E., Yang S. L. Further evidence concerning the autoantigenic status of the trophoblast. J Exp Med. 1972 May 1;135(5):1177–1184. doi: 10.1084/jem.135.5.1177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bradbury S., Billington W. D., Kirby D. R., Williams E. A. Surface mucin of human trophoblast. Am J Obstet Gynecol. 1969 Jun 1;104(3):416–418. doi: 10.1016/s0002-9378(16)34195-3. [DOI] [PubMed] [Google Scholar]
  11. Cochran A. J. Histology and prognosis in malignant melanoma. J Pathol. 1969 Mar;97(3):459–468. doi: 10.1002/path.1710970305. [DOI] [PubMed] [Google Scholar]
  12. Currie G. A., Bagshawe K. D. The masking of antigens on trophoblast and cancer cells. Lancet. 1967 Apr 1;1(7492):708–710. doi: 10.1016/s0140-6736(67)92183-6. [DOI] [PubMed] [Google Scholar]
  13. Currie G. A., Van Doorninck W., Bagshawe K. D. Effect of neuraminidase on the immunogenicity of early mouse trophoblast. Nature. 1968 Jul 13;219(5150):191–192. doi: 10.1038/219191a0. [DOI] [PubMed] [Google Scholar]
  14. DAMESHEK W. "Immunoblasts" and "immunocytes"--an attempt at a functional nomenclature. Blood. 1963 Feb;21:243–245. [PubMed] [Google Scholar]
  15. DOWLING E. A. Choriocarcinoma and hydatidiform mole as tissue transplants. South Med J. 1957 Feb;50(2):211–212. [PubMed] [Google Scholar]
  16. Elston C. W. Cellular reaction to choriocarcinoma. J Pathol. 1969 Feb;97(2):261–268. doi: 10.1002/path.1710970211. [DOI] [PubMed] [Google Scholar]
  17. HASKOVA V. Transplantation non-antigenicity of the foetal placenta. Nature. 1962 Jan 20;193:278–279. doi: 10.1038/193278b0. [DOI] [PubMed] [Google Scholar]
  18. HIRSCH H. M. Some aspects of the problem of immunity against transplanted and spontaneous tumors. Bacteriol Rev. 1962 Sep;26:336–353. doi: 10.1128/br.26.3.336-353.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hamlin I. M. Possible host resistance in carcinoma of the breast: a histological study. Br J Cancer. 1968 Sep;22(3):383–401. doi: 10.1038/bjc.1968.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Iliya F. A., Williamson S., Azar H. A. Choriocarcinoma in the Near East. Consanguinity as a possible etiologic factor. Cancer. 1967 Jan;20(1):144–149. doi: 10.1002/1097-0142(1967)20:1<144::aid-cncr2820200120>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  21. KIRBY D. R., BILLINGTON W. D., BRADBURY S., GOLDSTEIN D. J. ANTIGEN BARRIER OF THE MOUSE PLACENTA. Nature. 1964 Nov 7;204:548–549. doi: 10.1038/204548a0. [DOI] [PubMed] [Google Scholar]
  22. Lauder I., Aherne W. The significance of lymphocytic infiltration in neuroblastoma. Br J Cancer. 1972 Aug;26(4):321–330. doi: 10.1038/bjc.1972.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Laurence D. J., Neville A. M. Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review. Br J Cancer. 1972 Oct;26(5):335–355. doi: 10.1038/bjc.1972.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lawler S. D., Klouda P. T., Bagshawe K. D. The HL-A system in trophoblastic neoplasia. Lancet. 1971 Oct 16;2(7729):834–837. doi: 10.1016/s0140-6736(71)90217-0. [DOI] [PubMed] [Google Scholar]
  25. Lewis J. L., Jr, Terasaki P. I. HL-A leukocyte antigen studies in women with gestational trophoblastic neoplasms. Am J Obstet Gynecol. 1971 Oct 15;111(4):547–554. doi: 10.1016/0002-9378(71)90471-6. [DOI] [PubMed] [Google Scholar]
  26. Mellors R. C. Immunocytes and immunoglobulins. Blood. 1966 Jun;27(6):871–882. [PubMed] [Google Scholar]
  28. PREHN R. T. Specific homograft tolerance induced by successive matings and implications concerning choriocarcinoma. J Natl Cancer Inst. 1960 Oct;25:883–886. doi: 10.1093/jnci/25.4.883. [DOI] [PubMed] [Google Scholar]
  29. SCOTT J. S. Choriocarcinoma. Observations on the etiology. Am J Obstet Gynecol. 1962 Jan 15;83:185–193. [PubMed] [Google Scholar]
  30. SIMMONS R. L., RUSSELL P. S. The antigenicity of mouse trophoblast. Ann N Y Acad Sci. 1962 Oct 24;99:717–732. doi: 10.1111/j.1749-6632.1962.tb45356.x. [DOI] [PubMed] [Google Scholar]
  31. SUTHERLAND A. M. An unusual case of chorionepithelioma of the uterus. J Obstet Gynaecol Br Emp. 1951 Feb;58(1):29–32. doi: 10.1111/j.1471-0528.1951.tb04886.x. [DOI] [PubMed] [Google Scholar]

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