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. 1974 Feb;29(2):117–131. doi: 10.1038/bjc.1974.48

Anti-mitotic Activity of Bleomycin: Time of Action in the Mammalian Cell Cycle

D N Wheatley, G C Mueller, K Kajiwara
PMCID: PMC2008994  PMID: 4133781

Abstract

Bleomycin inhibits cell division in HeLa S-3 and other mammalian epithelial cell lines. Its effect on suspension cultured cells is far greater than on monolayer cells; this was found to be due partly to the absence of divalent ions. Other mammalian epithelial lines in suspension culture are very sensitive but fibroblastic cells (BHK 21/C13/DWS-3) grown under identical conditions are relatively insensitive. This study has established that bleomycin is a powerful anti-mitotic agent during the G2 phase but it does not prevent prophase cells from completing a normal mitotic division. Its ability to suppress DNA synthesis contributes little to the inhibition of cell cycling.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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