Abstract
A method of comparing differences in growth rates of tumours in small groups of animals is described. A common slope can be fitted to the growth curves of a given tumour in a group of isogeneic animals. Differences between growth potentials can be demonstrated by comparing the common slope for a given tumour against that of another tumour (or the same tumour at a later stage of development).
A highly significant difference is shown between the growth potential of an A-strain mammary carcinoma after 7 or after 28 days' growth in isogeneic animals. Since this increase in autonomy is reflected in the tumour's subsequent growth rate in secondary hosts, it is suggested that it involves adaptation of the tumour rather than progressive immunodepression of the primary host.
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Selected References
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- COLLINS V. P., LOEFFLER R. K., TIVEY H. Observations on growth rates of human tumors. Am J Roentgenol Radium Ther Nucl Med. 1956 Nov;76(5):988–1000. [PubMed] [Google Scholar]
- Cheshire P. J. The effect of multiple tumours on mammary tumour growth rates in the C3H mouse. Br J Cancer. 1970 Sep;24(3):542–547. doi: 10.1038/bjc.1970.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Denekamp J. The cellular proliferation kinetics of animal tumors. Cancer Res. 1970 Feb;30(2):393–400. [PubMed] [Google Scholar]
- Looney W. B., Mayo A. A., Allen P. M., Morrow J. Y., Morris H. P. A mathematical evaluation of tumour growth curves in rapid, intermediate and slow growing rat hepatomata. Br J Cancer. 1973 Apr;27(4):341–344. doi: 10.1038/bjc.1973.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rees J. A., Symes M. O. Further observations on whether host immunodepression is associated with tumour growth in mice. Br J Cancer. 1971 Sep;25(3):501–504. doi: 10.1038/bjc.1971.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rees J. A., Symes M. O. Immunodepression as a factor during 3-methylcholanthrene carcinogenesis and subsequent tumour growth in mice. Int J Cancer. 1973 Jan 15;11(1):202–211. doi: 10.1002/ijc.2910110124. [DOI] [PubMed] [Google Scholar]
- Rees J. A., Symes M. O. Observations on the increasing malignancy of tumours on prolonged growth: the influence of immunological changes in the host. Br J Cancer. 1971 Mar;25(1):121–129. doi: 10.1038/bjc.1971.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steel G. G., Adams K., Hodgett J., Janik P. Cell population kinetics of a spontaneous rat tumour during serial transplantation. Br J Cancer. 1971 Dec;25(4):802–811. doi: 10.1038/bjc.1971.94. [DOI] [PMC free article] [PubMed] [Google Scholar]