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. 1974 Apr;29(4):324–327. doi: 10.1038/bjc.1974.74

On the Methylated Purine Content of tRNA Present in Tumours

Ying Ho, Hsiang Ju Lin
PMCID: PMC2009170  PMID: 4853458

Abstract

The methylated purine content of tRNA bulk extracted from human hepatomata has been compared with that in normal human liver. The analyses were carried out with the aid of ion-exchange chromatography. The molar proportions of 5 bases detected in acid hydrolysates of tumour tRNA (N2-methylguanine, 1-methylguanine, 7-methylguanine, N2-dimethylguanine and 1-methyladenine) were not abnormally elevated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROMBERG P. A., GUTMAN A. B., WEISSMANN B. The purine bases of human urine. I. Separation and identification. J Biol Chem. 1957 Jan;224(1):407–422. [PubMed] [Google Scholar]
  2. BROMBERG P. A., GUTMAN A. B., WEISSMANN B. The purine bases of human urine. II. Semiquantitative estimation and isotope incorporation. J Biol Chem. 1957 Jan;224(1):423–434. [PubMed] [Google Scholar]
  3. BRUNNGRABER E. F. A simplified procedure for the preparation of "soluble" RNA from rat liver. Biochem Biophys Res Commun. 1962 Jun 19;8:1–3. doi: 10.1016/0006-291x(62)90223-1. [DOI] [PubMed] [Google Scholar]
  4. HEMMENS W. F. NEO-GUANYLIC ACID PRODUCED BY THE ACTION OF ACID ON RIBONUCLEIC ACID. Biochim Biophys Acta. 1964 Oct 16;91:332–334. doi: 10.1016/0926-6550(64)90260-9. [DOI] [PubMed] [Google Scholar]
  5. Inose M., Miyata S., Iwanami Y. Methylation patterns of transfer RNA from ascites hepatomas. Biochim Biophys Acta. 1972 Jan 18;259(1):96–103. doi: 10.1016/0005-2787(72)90476-5. [DOI] [PubMed] [Google Scholar]
  6. Iwanami Y., Brown G. M. Methylated bases of transfer ribonucleic acid from HeLa and L cells. Arch Biochem Biophys. 1968 Mar 20;124(1):472–482. doi: 10.1016/0003-9861(68)90355-x. [DOI] [PubMed] [Google Scholar]
  7. McCoy T. A., Carter E. A. The separation of ribonucleic acids on sephadex columns. J Chromatogr. 1968 Oct 22;37(3):458–462. doi: 10.1016/s0021-9673(01)99141-1. [DOI] [PubMed] [Google Scholar]
  8. Mirvish S. S., Medalie J., Linsell C. A., Yousuf E., Reyad S. 7-methylguanine and other minor urinary purines: values for normal subjects from Israel, Gaza, and Kenya, and for patients with cancer of various organs or cirrhosis of the liver. Cancer. 1971 Mar;27(3):736–743. doi: 10.1002/1097-0142(197103)27:3<736::aid-cncr2820270334>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  9. Randerath K. Application of a tritium derivative method to human brain and brain tumor transfer RNA analysis. Cancer Res. 1971 May;31(5):658–661. [PubMed] [Google Scholar]
  10. SRINIVASAN P. R., BOREK E. ENZYMATIC ALTERATION OF NUCLEIC ACID STRUCTURE. Science. 1964 Aug 7;145(3632):548–553. doi: 10.1126/science.145.3632.548. [DOI] [PubMed] [Google Scholar]
  11. Viale G. L. Transfer RNA and transfer RNA methylase in human brain tumors. Cancer Res. 1971 May;31(5):605–608. [PubMed] [Google Scholar]

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