Abstract
The formation of N-nitrosopyrrolidine from sodium nitrite and pyrrolidine in vivo in a dog's stomach is demonstrated. The rate of formation of nitrosopyrrolidine is shown to be subject to pronounced catalytic effects. Nitrosopyrrolidine is also shown to disappear rapidly from the stomach, probably due to absorption.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alam B. S., Saporoschetz I. B., Epstein S. S. Formation of N-nitrosopiperidine from piperidine and sodium nitrite in the stomach and the isolated intestinal loop of the rat. Nature. 1971 Jul 9;232(5306):116–118. doi: 10.1038/232116a0. [DOI] [PubMed] [Google Scholar]
- Fan T. Y., Tannenbaum S. R. Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite: acceleration by thiocyanate and other anions. J Agric Food Chem. 1973 Mar-Apr;21(2):237–240. doi: 10.1021/jf60186a006. [DOI] [PubMed] [Google Scholar]
- Friedman M. A., Greene E. J., Epstein S. S. Rapid gastric absorption of sodium nitrite in mice. J Pharm Sci. 1972 Sep;61(9):1492–1494. doi: 10.1002/jps.2600610937. [DOI] [PubMed] [Google Scholar]
- Greenblatt M., Lijinsky W. Nitrosamine studies: neoplasms of liver and genital mesothelium in nitrosopyrrolidine-treated MRC rats. J Natl Cancer Inst. 1972 Jun;48(6):1687–1696. [PubMed] [Google Scholar]
- Lane R. P., Bailey M. E. The effect of pH on dimethylnitrosamine formation in human gastric juice. Food Cosmet Toxicol. 1973 Oct;11(5):851–854. doi: 10.1016/0015-6264(73)90144-2. [DOI] [PubMed] [Google Scholar]
- Lijinsky W., Epstein S. S. Nitrosamines as environmental carcinogens. Nature. 1970 Jan 3;225(5227):21–23. doi: 10.1038/225021a0. [DOI] [PubMed] [Google Scholar]
- Magee P. N., Barnes J. M. Carcinogenic nitroso compounds. Adv Cancer Res. 1967;10:163–246. doi: 10.1016/s0065-230x(08)60079-2. [DOI] [PubMed] [Google Scholar]
- Ndwberne P. M., Shank R. C. Induction of liver and lung tumours in rats by the simultaneous administration of sodium nitrite and morpholine. Food Cosmet Toxicol. 1973 Oct;11(5):819–825. doi: 10.1016/0015-6264(73)90140-5. [DOI] [PubMed] [Google Scholar]
- Sander J. Kann Nitrit in der menschlichen Nahrung Ursache einer Krebsentstehung durch Nitrosaminbildung sein? Arch Hyg Bakteriol. 1967 May;151(1):22–28. [PubMed] [Google Scholar]
- Sander J., Seif F. Bakterielle Reduktion von Nitrat im Magen des Menschen als Ursache einer Nitrosamin-Bildung. Arzneimittelforschung. 1969 Jul;19(7):1091–1093. [PubMed] [Google Scholar]