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. 1974 Aug;30(2):129–135. doi: 10.1038/bjc.1974.123

The Inhibition of Arginase by Proline in Cell-free Extracts of Mouse Mammary Tumour

K V Kesava Rao, S R Pai, C V Bapat
PMCID: PMC2009223  PMID: 4421360

Abstract

Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that proline inhibits the arginase activity by competing directly at the active site without conformational change. The inhibition may be of regulatory importanec, involving a feedback mechenism in mammary tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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