Abstract
C3H mice were implanted with pieces of spontaneous mammary carcinoma which were irradiated or removed surgically when they had grown to 6·5 mm mean diameter. The incidence of lung metastases was determined from samples taken at various times up to 6 months later. Single x-ray doses and fractionated schedules up to 15 fractions in 18 days were used, no significant difference being observed in the results for all these schedules.
On the major question of whether radiation caused an increase in the number of lung metastases the study is inconclusive. The incidence of metastases was found to be 8% if the implanted tumour was cured by the radiation, whereas if the radiotherapy did not cure the tumours the incidence was 35%. This difference between the two groups was significant. If tumours recurred locally after radiotherapy and were then removed surgically, the incidence of lung metastases was significantly greater than that after surgery of unirradiated tumours. The incidence of metastases was similar after curative surgery and after curative radiotherapy.
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Selected References
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- OLCH P. D., ECK R. V., SMITH R. R. An experimental study of the effect of external irradiation on a primary tumor and its distant metastases. Cancer. 1959 Jan-Feb;12(1):23–26. doi: 10.1002/1097-0142(195901/02)12:1<23::aid-cncr2820120107>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
- Sheldon P. W., Fowler J. F. The effect of irradiating a transplanted murine lymphosarcoma on the subsequent development of metastases. Br J Cancer. 1973 Dec;28(6):508–514. doi: 10.1038/bjc.1973.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VON ESSEN C. F., KAPLAN H. S. Further studies on metastasis of a transplantable mouse mammary carcinoma after roentgen irradiation. J Natl Cancer Inst. 1952 Feb;12(4):883–892. [PubMed] [Google Scholar]
- Van den Brenk H. A., Sharpington C. Effect of local x-irradiation of a primary sarcoma in the rat on dissemination and growth of metastases: dose-response characteristics. Br J Cancer. 1971 Dec;25(4):812–830. doi: 10.1038/bjc.1971.95. [DOI] [PMC free article] [PubMed] [Google Scholar]