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. 1974 Oct;30(4):325–331. doi: 10.1038/bjc.1974.200

Studies on the Mechanisms of Chemical Leukaemogenesis

T M Dexter, R Schofield, L G Lajtha, M Moore
PMCID: PMC2009288  PMID: 4614855

Abstract

Following a single injection of MNU into “intact” mice, a high incidence of leukaemia (90%) is obtained, with a 50% induction time of 200 days. Immunological studies indicate that the θ antigen is expressed on the leukaemic cells. Thymectomized MNU treated mice had a 50% induction time of 500 days, and the incidence was somewhat lower. Leukaemias failed to develop in MNU treated T lymphocyte deficient animals and in lethally irradiated, or thymectomized lethally irradiated mice reconstituted with MNU treated bone marrow. It is suggested that the T lymphocytes rather than the haemopoietic stem cells or pre-T cells are the “target cells” in MNU leukaemogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DRUCKREY H., STEINHOFF D., PREUSSMANN R., IVANKOVIC S. ERZEUGUNG VON KREBS DURCH EINE EINMALIGE DOSIS VON METHYLNITROSO-HARNSTOFF UND VERSCHIEDENEN DIALKYLNITROSAMINEN AN RATTEN. Z Krebsforsch. 1964 Feb 7;66:1–10. [PubMed] [Google Scholar]
  2. Druckrey H., Preussmann R., Ivankovic S., Schmähl D. Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z Krebsforsch. 1967;69(2):103–201. [PubMed] [Google Scholar]
  3. Haran-Chera N., Peled A. Thymus and bone marrow derived lymphatic leukaemia in mice. Nature. 1973 Feb 9;241(5389):396–398. doi: 10.1038/241396a0. [DOI] [PubMed] [Google Scholar]
  4. Haran-Ghera N. Relationship between tumour cell and host in chemical leukaemogenesis. Nat New Biol. 1973 Nov 21;246(151):84–86. doi: 10.1038/newbio246084a0. [DOI] [PubMed] [Google Scholar]
  5. Joshi V. V., Frei J. V. Gross and microscopic changes in the lymphoreticular system during genesis of malignant lymphoma induced by a single injection of methylnitrosourea in adult mice. J Natl Cancer Inst. 1970 Feb;44(2):379–394. [PubMed] [Google Scholar]
  6. KAPLAN H. S., BROWN M. B., PAULL J. Influence of postirradiation thymectomy and of thymic implants on lymphoid tumor incidence in C57BL mice. Cancer Res. 1953 Sep;13(9):677–680. [PubMed] [Google Scholar]
  7. KAPLAN H. S. Influence of thymectomy, splenectomy, and gonadectomy on incidence of radiation-induced lymphoid tumors in strain C57 black mice. J Natl Cancer Inst. 1950 Aug;11(1):83–90. [PubMed] [Google Scholar]
  8. LAW L. W., MILLER J. H. The influence of thymectomy on the incidence of carcinogen-induced leukemia in strain DBA mice. J Natl Cancer Inst. 1950 Oct;11(2):425–437. [PubMed] [Google Scholar]
  9. Miller J. F., Mitchell G. F. Thymus and antigen-reactive cells. Transplant Rev. 1969;1:3–42. doi: 10.1111/j.1600-065x.1969.tb00135.x. [DOI] [PubMed] [Google Scholar]
  10. Peled A., Haran-Ghera N. Immunosuppression by the radiation leukemia virus and its relation to lymphatic leukemia development. Int J Cancer. 1971 Jul 15;8(1):97–106. doi: 10.1002/ijc.2910080113. [DOI] [PubMed] [Google Scholar]
  11. REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Raff M. C., Sternberg M., Taylor R. B. Immunoglobulin determinants on the surface of mouse lymphoid cells. Nature. 1970 Feb 7;225(5232):553–554. doi: 10.1038/225553a0. [DOI] [PubMed] [Google Scholar]
  13. Schofield R., Cole L. J. An erythrocyte defect in splenectomized x-irradiated mice restored with spleen colony cells. Br J Haematol. 1968 Feb;14(2):131–140. doi: 10.1111/j.1365-2141.1968.tb01482.x. [DOI] [PubMed] [Google Scholar]
  14. TILL J. E., McCULLOCH E. A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 1961 Feb;14:213–222. [PubMed] [Google Scholar]
  15. UPTON A. C., WOLFF F. F., FURTH J., KIMBALL A. W. A comparison of the induction of myeloid and lymphoid leukemias in x-radiated RF mice. Cancer Res. 1958 Aug;18(7):842–848. [PubMed] [Google Scholar]
  16. WIGZELL H. QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS. Transplantation. 1965 May;3:423–431. doi: 10.1097/00007890-196505000-00011. [DOI] [PubMed] [Google Scholar]

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