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. 1974 Oct;30(4):349–354. doi: 10.1038/bjc.1974.204

Intra-Arterial Infusion with Methotrexate in the Rat

P J Sindram, G B Snow, L M van Putten
PMCID: PMC2009300  PMID: 4548653

Abstract

The superiority of intra-arterial infusion with methotrexate (MTX) over its systemic use in the treatment of head and neck tumours is still being questioned. A model in the rat, suitable for intra-arterial administration of MTX could be constructed. In this model 3 schedules have been investigated: (1) 7 days continuous intra-arterial infusion with MTX; (2) the same schedule combined with leucovorin (CF) 6-hourly intraperitoneally (i.p.) after Sullivan et al. (1959); (3) intermittent administration of MTX 2 × 24 h intra-arterial infusion on Day 1 and 4, while on Day 2, 3, 5, 6 and 7 the catheter is kept open by the continuous intra-arterial infusion of saline. For all the three schedules intra-arterial MTX proved to be superior to its systemic use.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bilder J., Hornová J. Analysis of the results of regional chemotherapy for carcinomas of the orofacial region. Neoplasma. 1970;17(1):85–92. [PubMed] [Google Scholar]
  2. Capizzi R. L., DeConti R. C., Marsh J. C., Bertino J. R. Methotrexate therapy of head and neck cancer: improvement in therapeutic index by the use of leucovorin "rescue". Cancer Res. 1970 Jun;30(6):1782–1788. [PubMed] [Google Scholar]
  3. Couture J., Deschênes L. Intra-arterial infusion--an adjuvant to the treatment of oral carcinoma. Cancer. 1972 Jun;29(6):1632–1636. doi: 10.1002/1097-0142(197206)29:6<1632::aid-cncr2820290630>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  4. Franchi G., Moretti L., Garattini S. Experimental chemotherapy of a transplantable rhabdomyosarcoma in the rat. Eur J Cancer. 1970 Oct;6(5):441–443. doi: 10.1016/0014-2964(70)90043-5. [DOI] [PubMed] [Google Scholar]
  5. Freckman H. A. Results in 169 patients with cancer of the head and neck treated by intra-arterial infusion therapy. Am J Surg. 1972 Oct;124(4):501–509. doi: 10.1016/0002-9610(72)90075-x. [DOI] [PubMed] [Google Scholar]
  6. GOLDIN A., VENDITTI J. M., HUMPHREYS S. R., DENNIS D., MANTEL N. Studies on the management of mouse leukemia (L1210) with antagonists of folic acid. Cancer Res. 1955 Dec;15(11):742–747. [PubMed] [Google Scholar]
  7. HELLMAN S., IANNOTTI A. T., BERTINO J. R. DETERMINATIONS OF THE LEVELS OF SERUM FOLATE IN PATIENTS WITH CARCINOMA OF THE HEAD AND NECK TREATED WITH METHOTREXATE. Cancer Res. 1964 Jan;24:105–113. [PubMed] [Google Scholar]
  8. HUSEBY R. A., DOWNING V. The use of methotrexate orally in treatment of squamous cancers of the head and neck. Cancer Chemother Rep. 1962 Feb;16:511–514. [PubMed] [Google Scholar]
  9. Healy J. B., Moriarty M. J., Maddock P. G. Treatment of advanced cancer of head and neck by large doses of methotrexate. J Ir Med Assoc. 1971 Jul 22;64(416):376–379. [PubMed] [Google Scholar]
  10. Lefkowitz E., Papac R. J., Bertino J. R. Head and neck cancer. 3. Toxicity of 24-hour infusions of methotrexate (NSC-740) and protection by leucovorin (NSC-3590) in patients with epidermoid carcinomas. Cancer Chemother Rep. 1967 Sep;51(5):305–311. [PubMed] [Google Scholar]
  11. Leone L. A., Albala M. M., Rege V. B. Treatment of carcinoma of the head and neck with intravenous methotrexate. Cancer. 1968 May;21(5):828–837. doi: 10.1002/1097-0142(196805)21:5<828::aid-cncr2820210507>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  12. PAPAC R. J., JACOBS E. M., FOYE L. V., Jr, DONOHUE D. M. SYSTEMIC THERAPY WITH AMETHOPTERIN IN SQUAMOUS CARCINOMA OF THE HEAD AND NECK. Cancer Chemother Rep. 1963 Oct;32:47–54. [PubMed] [Google Scholar]
  13. Papac R., Lefkowitz E., Bertino J. R. Methotrexate (NSC-740) in squamous cell carcinoma of the head and neck. II. Intermittent intravenous therapy. Cancer Chemother Rep. 1967 Apr;51(2):69–72. [PubMed] [Google Scholar]
  14. Priestman T. J. Results in fifty cases of advanced squamous cell carcinoma of the head and neck treated by intravenous chemotherapy. Br J Cancer. 1973 May;27(5):400–405. doi: 10.1038/bjc.1973.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SULLIVAN R. D., MILLER E., SIKES M. P. Antimetabolite-metabolite combination cancer chemotherapy. Effects of intraarterial methotrexate-intramuscular Citrovorum factor therapy in human cancer. Cancer. 1959 Nov-Dec;12:1248–1262. doi: 10.1002/1097-0142(195911/12)12:6<1248::aid-cncr2820120619>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  16. Snow G. B., Sindram P. J. Intra-arterial infusion chemotherapy in head and neck cancer. A clinical and experimental study. Arch Chir Neerl. 1973;25(4):363–377. [PubMed] [Google Scholar]

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