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. 1974 Nov;30(5):477–480. doi: 10.1038/bjc.1974.224

The binding of 14C labelled 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) to macromolecules of sensitive and resistant tumours.

T A Connors, J R Hare
PMCID: PMC2009303  PMID: 4469198

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alonso A., Arnold H. P. Stimulation of amino acids incorporation into rat liver nonhistone chromatin proteins after treatment with diethyl-nitrosamine. FEBS Lett. 1974 Apr 15;41(1):8–10. doi: 10.1016/0014-5793(74)80940-3. [DOI] [PubMed] [Google Scholar]
  2. Audette R. C., Connors T. A., Mandel H. G., Merai K., Ross W. C. Studies on the mechanism of action of the tumour inhibitory triazenes. Biochem Pharmacol. 1973 Aug 1;22(15):1855–1864. doi: 10.1016/0006-2952(73)90045-2. [DOI] [PubMed] [Google Scholar]
  3. Ball C. R., Connors T. A., Double J. A., Ujhazy V., Whisson M. E. Comparison of nitrogen-mustard sensitive and -resistant Yoshida sarcomas. Int J Cancer. 1966 Jul 15;1(4):319–327. doi: 10.1002/ijc.2910010403. [DOI] [PubMed] [Google Scholar]
  4. Bhattacharya R. K., Schultze M. O. Protective effects of histones against drug-induced alterations of deoxyribonucleic acid in thymus chromatin. Biochem Pharmacol. 1974 May 15;23(10):1519–1529. doi: 10.1016/0006-2952(74)90389-x. [DOI] [PubMed] [Google Scholar]
  5. Bray D. A., DeVita V. T., Adamson R. H., Oliverio V. T. Effects of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) and its degradation products on progression of L1210 cells through the cell cycle. Cancer Chemother Rep. 1971 Jun;55(3):215–220. [PubMed] [Google Scholar]
  6. Cheng C. J., Fujimura S., Grunberger D., Weinstein I. B. Interaction of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) with nucleic acids and proteins in vivo and in vitro. Cancer Res. 1972 Jan;32(1):22–27. [PubMed] [Google Scholar]
  7. Gale G. R. Effect of 1,3-bis-(2-chloroethyl)-1-nitrosourea on Saccharomyces cerevisiae. Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1004–1010. doi: 10.3181/00379727-119-30361. [DOI] [PubMed] [Google Scholar]
  8. Montgomery J. A., James R., McCaleb G. S., Johnston T. P. The modes of decomposition of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds. J Med Chem. 1967 Jul;10(4):668–674. doi: 10.1021/jm00316a033. [DOI] [PubMed] [Google Scholar]
  9. Oliverio V. T. Toxicology and pharmacology of the nitrosoureas. Cancer Chemother Rep 3. 1973 May;4(3):13–20. [PubMed] [Google Scholar]
  10. PITTILLO R. F., NARKATES A. J., BURNS J. MICROBIOLOGICAL EVALUATION OF 1,3-BIS (2-CHLOROETHYL)-I-NITROSOUREA. Cancer Res. 1964 Aug;24:1222–1228. [PubMed] [Google Scholar]
  11. Pascoe J. M., Roberts J. J. Interactions between mammalian cell DNA and inorganic platinum compounds. II. Interstrand cross-linking of isolated and cellular DNA by platinum(IV) compounds. Biochem Pharmacol. 1974 May 1;23(9):1345–1357. doi: 10.1016/0006-2952(74)90354-2. [DOI] [PubMed] [Google Scholar]
  12. Riches P. G., Harrap K. R. Some effects of chlorambucil on the chromatin of Yoshida ascites sarcoma cells. Cancer Res. 1973 Feb;33(2):389–393. [PubMed] [Google Scholar]
  13. SCHABEL F. M., Jr, JOHNSTON T. P., McCALEB G. S., MONTGOMERY J. A., LASTER W. R., SKIPPER H. E. Experimental evaluation of potential anticancer agents VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia. Cancer Res. 1963 Jun;23:725–733. [PubMed] [Google Scholar]
  14. Schmall B., Cheng C. J., Fujimura S., Gersten N., Grunberger D., Weinstein I. B. Modification of proteins by 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (nsc 79037) in vitro. Cancer Res. 1973 Aug;33(8):1921–1924. [PubMed] [Google Scholar]
  15. Schmid F. A., Hutchison D. J. Collateral sensitivity of resistant lines of mouse leukemias L1210 and L5178Y. Cancer Res. 1972 Apr;32(4):808–812. [PubMed] [Google Scholar]
  16. Shirakawa S., Frei E., 3rd Comparative effects of the antitumor agents 5-(Dimethyltriazeno)-imidazole-4-carboxamide and 1,3-bis(2-chloroethyl)-1-nitrosourea on cell cycle of L1210 leukemia cells in vivo. Cancer Res. 1970 Aug;30(8):2173–2190. [PubMed] [Google Scholar]
  17. Wheeler G. P., Bowdon B. J. Some effects of 1, 3-bis(2-chloroethyl)-1-nitrosourea upon the synthesis of protein and nucleic acids in vivo and in vitro. Cancer Res. 1965 Nov;25(10):1770–1778. [PubMed] [Google Scholar]
  18. Wheeler G. P., Chumley S. Alkylating activity of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds. J Med Chem. 1967 Mar;10(2):259–261. doi: 10.1021/jm00314a032. [DOI] [PubMed] [Google Scholar]

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