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. 1974 Nov;30(5):448–458. doi: 10.1038/bjc.1974.219

On the Theory of Clonal Selection in Carcinogenic Transformation

P M Naha, M Ashworth
PMCID: PMC2009312  PMID: 4469197

Abstract

A temperature sensitive variant (ts13) of African green monkey kidney cell line, carrying a temperature sensitive lesion in thymidine metabolism, was transformed by 40 μg/ml of methylnitrosourea (MNU) at the restricted temperature of 39·5°C, whereas the same cell line was not transformed by MNU at the permissive temperature of 33°C. Results presented in this paper raise the possibility that clones of cells carrying a biochemical lesion might possibly contribute to carcinogenesis with respect to certain chemical carcinogens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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