Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1974 Dec;30(6):532–537. doi: 10.1038/bjc.1974.232

Clinical Evaluation of the Macrophage Electrophoretic Mobility Test for Cancer

R M Lewkonia, E J L Kerr, W J Irvine
PMCID: PMC2009344  PMID: 4447784

Abstract

Experience with the macrophage electrophoretic mobility (MEM) test of Field and Caspary in subjects with malignant and non-malignant disease is reported. There was some discrimination between groups of patients with benign and malignant lesions but there was no clear separation between the groups. A trial of the Cardiff modification of the test failed to discriminate between groups of patients with benign and malignant chest disease. In the view of the authors the MEM test in its present form is not sufficiently reproducible to warrant more general clinical application as an in vitro test for cancer.

Full text

PDF
532

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander P. Foetal "antigens" in cancer. Nature. 1972 Jan 21;235(5334):137–140. doi: 10.1038/235137a0. [DOI] [PubMed] [Google Scholar]
  2. Caspary E. A., Field E. J. Specific lymphocyte sensitization in cancer: is there a common antigen in human malignant neoplasia? Br Med J. 1971 Jun 12;2(5762):613–617. doi: 10.1136/bmj.2.5762.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Caspary E. A. Lymphocyte-antigen interaction in electrophoretic mobility test for cellular sensitization. Nat New Biol. 1971 May 5;231(18):24–24. doi: 10.1038/newbio231024a0. [DOI] [PubMed] [Google Scholar]
  4. Cercek L., Cercek B., Franklin C. I. Biophysical differentiation between lymphocytes from healthy donors, patients with malignant diseases and other disorders. Br J Cancer. 1974 May;29(5):345–352. doi: 10.1038/bjc.1974.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Field E. J., Caspary E. A. Lymphocyte sensitisation: an in-vitro test for cancer? Lancet. 1970 Dec 26;2(7687):1337–1341. doi: 10.1016/s0140-6736(70)92361-5. [DOI] [PubMed] [Google Scholar]
  6. Goldstone A. H., Kerr L., Irvine W. J. The macrophage electrophoretic migration test in cancer. Clin Exp Immunol. 1973 Jul;14(3):469–472. [PMC free article] [PubMed] [Google Scholar]
  7. Pritchard J. A., Moore J. L., Sutherland W. H., Joslin C. A. Evaluation and development of the macrophage electrophoretic mobility (MEM) test for malignant disease. Br J Cancer. 1973 Jan;27(1):1–9. doi: 10.1038/bjc.1973.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Walker W. S. Functional heterogeneity of macrophages: subclasses of peritoneal macrophages with different antigen-binding activities and immune complex receptors. Immunology. 1974 May;26(5):1025–1037. [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES