Abstract
The evolution of metastatic colorectal cancer in patients who have had surgical treatment for a primary lesion was studied in relation the progressive changes in the blood levels of carcinembryonic antigen (CEA), to gamma glutamyl transpeptidase (GGT) and routine liver function tests (LFTs). Involvement of the liver could ofter be reliably predicted many weeks in advance of clinical diagnosis while metastases to other sites were less likely to be detected early by this test. The association of the extent of disease with the patterns of biochemical changes is discussed with reference to several illustrative examples.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Boone D. J., Routh J. I., Schrantz R. Gamma-glutamyl transpeptidase and 5'-nucleotidase. Comparison as diagnostics for hepatic disease. Am J Clin Pathol. 1974 Mar;61(3):321–327. doi: 10.1093/ajcp/61.3.321. [DOI] [PubMed] [Google Scholar]
- Cooper E. H., Turner R., Steele L., Goligher J. C. Blood muramidase activity in colorectal cancer. Br Med J. 1974 Sep 14;3(5932):662–664. doi: 10.1136/bmj.3.5932.662. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mackay A. M., Patel S., Carter S., Stevens U., Laurence D. J., Cooper E. H., Neville A. M. Role of serial plasma C.E.A. assays in detection of recurrent and metastatic colorectal carcinomas. Br Med J. 1974 Nov 16;4(5941):382–385. doi: 10.1136/bmj.4.5941.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Skarin A. T., Delwiche R., Zamcheck N., Lokich J. J., Frei E., 3rd Carcinoembryonic antigen: clinical correlation with chemotherapy for metastatic gastrointestinal cancer. Cancer. 1974 May;33(5):1239–1245. doi: 10.1002/1097-0142(197405)33:5<1239::aid-cncr2820330508>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
- Sorokin J. J., Sugarbaker P. H., Zamcheck N., Pisick M., Kupchik H. Z., Moore F. D. Serial carcinoembryonic antigen assays. Use in detection of cancer recurrence. JAMA. 1974 Apr 1;228(1):49–53. [PubMed] [Google Scholar]
- Steele L., Cooper E. H., Mackay A. M., Losowsky M. S., Goligher J. C. Combination of carcinoembryonic antigen and gamma glutamyl transpeptidase in the study of the evolution of colorectal cancer. Br J Cancer. 1974 Oct;30(4):319–324. doi: 10.1038/bjc.1974.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Willig F., Greiner I., Stork H., Schmidt F. H. Leucinaminopeptidase-(Arylamidase-) Aktivität im Serum Bestimmung mit Leucin-p-nitroanilid als Substrat. Klin Wochenschr. 1967 May 1;45(9):474–481. doi: 10.1007/BF01717434. [DOI] [PubMed] [Google Scholar]