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. 1975 Feb;31(2):182–188. doi: 10.1038/bjc.1975.24

The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice.

P L Grover, P Sims, B C Mitchley, F J Roe
PMCID: PMC2009384  PMID: 1164468

Abstract

Benz(a)anthracene injected subcutaneously during the first 3 days of life caused a dose related increase in the incidence of liver and lung tumours in Swiss mice but over a similar dose range, the K region epoxide of benz(a)anthracene was less effective. Neonatally injected 7-methylbenz(a) was considerably more active than its K region epoxide in increasing the incidence of liver tumours in males. Both the parent compound and the epoxide slightly raised the incidence of lung tumours. Both chrysene and its K region epoxide increased liver tumour incidence but not lung tumour incidence. The K region epoxides of dibenz(a,h)-anthracene and 3-methylcholanthrene were without apparent effect on the incidence of liver, lung or other tumours despite indications from previously reported studies that the parent hydrocarbons are active at the same dose levels. The K region epoxide of phenanthrene had no effect on the incidence of any kind of neoplasm.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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