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. 1975 Feb;31(2):157–163. doi: 10.1038/bjc.1975.20

Studies on the effector cell of anti-tumour immunity in a chemically induced mouse tumour system.

R B Whitney, J G Levy, A G Smith
PMCID: PMC2009404  PMID: 1080668

Abstract

Spleen cells from mice immunized against a methylcholanthrene induced rhabdomyosarcoma inhibited tumour cell colony formation in vitro and prevented tumour development in vivo in an adoptive transfer test. Treatment of the immune spleen cells with anti-mouse immunoglobulin serum or passage through a nylon wool column, both of which reduced the percentage of immunoglobulin bearing cells in the population to less than 3-4%, did not alter their anti-tumour effects. In contrast, treatment of the spleen cells with anti-BAomicron serum abolished their anti-tumour effects both in vitro and in vivo. These results indicate that T cells are the mediators of tumour immunity in this chemically induced tumour system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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