Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1975 Feb;31(2):176–181. doi: 10.1038/bjc.1975.23

Methanol extraction residue of BCG in the treatment of transplanted rat tumours.

D G Hopper, M V Pimm, R W Baldwin
PMCID: PMC2009408  PMID: 169861

Abstract

Subcutaneous growth of immunogenic chemically induced rat sarcomata and a hepatoma was restricted when cells were injected into syngeneic animals in admixture with MER. Rats rejecting mixed inocula were immune to further challenge with the same tumour. Growth of a chemically induced mammary carcinoma which lacks detectable immunogenicity was suppressed when low cell inocula were injected in admixture with MER or intact BCG organisms, although animals were not immune to re-challenge. These studies indicate that clinically MER may be a suitable alternative to BCG for contact suppression of tumour growth or incorporation into tumour cell:adjuvant vaccines for active immunotherapy.

Full text

PDF
176

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin R. W., Cook A. J., Hopper D. G., Pimm M. V. Radiation-killed BCG in the treatment of transplanted rat tumours. Int J Cancer. 1974 Jun 15;13(6):743–750. doi: 10.1002/ijc.2910130602. [DOI] [PubMed] [Google Scholar]
  2. Baldwin R. W., Pimm M. V. B.C.G. suppression of pulmonary metastases from primary rat hepatomata. Br J Cancer. 1974 Nov;30(5):473–476. doi: 10.1038/bjc.1974.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baldwin R. W., Pimm M. V. BCG immunotherapy of a rat sarcoma. Br J Cancer. 1973 Oct;28(4):281–287. doi: 10.1038/bjc.1973.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Baldwin R. W., Pimm M. V. BCG immunotherapy of pulmonary growths from intravenously transferred rat tumour cells. Br J Cancer. 1973 Jan;27(1):48–54. doi: 10.1038/bjc.1973.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Baldwin R. W., Pimm M. V. BGG immunotherapy of local subcutaneous growths and post-surgical pulmonary metastases of a transplanted rat epithelioma of spontaneous origin. Int J Cancer. 1973 Sep 15;12(2):420–427. doi: 10.1002/ijc.2910120213. [DOI] [PubMed] [Google Scholar]
  6. Baldwin R. W., Pimm M. V. Influence of BCG infection on growth of 3-methylcholanthrene-induced rat sarcomas. Rev Eur Etud Clin Biol. 1971 Nov;16(9):875–881. [PubMed] [Google Scholar]
  7. Bartlett G. L., Zbar B., Rapp H. J. Suppression of murine tumor growth by immune reaction to the Bacillus Calmette-Guérin strain of Mycobacterium bovis. J Natl Cancer Inst. 1972 Jan;48(1):245–257. [PubMed] [Google Scholar]
  8. Bartlett G. L., Zbar B. Tumor-specific vaccine containing Mycobacterium bovis and tumor cells: safety and efficacy. J Natl Cancer Inst. 1972 Jun;48(6):1709–1726. [PubMed] [Google Scholar]
  9. Bornstein R. S., Mastrangelo M. J., Sulit H., Chee D., Yarbro J. W., Prehn L. M., Prehn R. T. Immunotherapy of melanoma with intralesional BCG. Natl Cancer Inst Monogr. 1973 Dec;39:213–220. [PubMed] [Google Scholar]
  10. Chung E. B., Zbar B., Rapp H. J. Tumor regression mediated by Mycobacterium bovis (strain BCG). Effects of isonicotinic acid hydrazide, cortisone acetate, and antithymocyte serum. J Natl Cancer Inst. 1973 Jul;51(1):241–250. doi: 10.1093/jnci/51.1.241. [DOI] [PubMed] [Google Scholar]
  11. Hunt J. S., Silverstein M. J., Sparks F. C., Haskell C. M., Pilch Y. H., Morton D. L. Granulomatous hepatitis: a complication of B.C.G. immunotherapy. Lancet. 1973 Oct 13;2(7833):820–821. doi: 10.1016/s0140-6736(73)90860-x. [DOI] [PubMed] [Google Scholar]
  12. Morton D. L., Eilber F. R., Joseph W. L., Wood W. C., Trahan E., Ketcham A. S. Immunological factors in human sarcomas and melanomas: a rational basis for immunotherapy. Ann Surg. 1970 Oct;172(4):740–749. doi: 10.1097/00000658-197010000-00018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pinsky C. M., Hirshaut Y., Oettgen H. F. Treatment of malignant melanoma by intratumoral injection of BCG. Natl Cancer Inst Monogr. 1973 Dec;39:225–228. [PubMed] [Google Scholar]
  14. Sokal J. E., Aungst C. W., Grace J. T., Jr Immunotherapy in well-controlled chronic myelocytic leukemia. N Y State J Med. 1973 May 15;73(10):1180–1185. [PubMed] [Google Scholar]
  15. Sparks F. C., Silverstein M. J., Hunt J. S., Haskell C. M., Pilch Y. H., Morton D. L. Complications of BCG immunotherapy in patients with cancer. N Engl J Med. 1973 Oct 18;289(16):827–830. doi: 10.1056/NEJM197310182891603. [DOI] [PubMed] [Google Scholar]
  16. Weiss D. W. Nonspecific stimulation and modulation of the immune response and of states of resistance by the methanol-extraction residue fraction of tubercle bacilli. Natl Cancer Inst Monogr. 1972 Dec;35:157–171. [PubMed] [Google Scholar]
  17. Zbar B., Bernstein I. D., Rapp H. J. Suppression of tumor growth at the site of infection with living Bacillus Calmette-Guérin. J Natl Cancer Inst. 1971 Apr;46(4):831–839. [PubMed] [Google Scholar]
  18. Zbar B., Rapp H. J., Ribi E. E. Tumor suppression by cell walls of mycobacterium bovis attached to oil droplets. J Natl Cancer Inst. 1972 Mar;48(3):831–835. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES