Abstract
Mice were given a single dose of nitrosolimethylamine, nitrosoliethylamine or nitrosomethylethylamine and the yield of tumours and related lesions in the livers determined 12 months later. A hepatonecrotic dose of CCl4 24 or 48 h before the nitrosamines, increased the yields of hepatocellular tumours and proliferative foci in the livers, whereas when given 60 h before the nitrosamines there was no significant effect.
Full text
PDF








Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barker E. A., Arcasoy M., Smuckler E. A. A comparison of the effects of partial surgical and partial chemical (CCl 4) hepatectomy on microsomal cytochrome b 5 and P 450 and oxidative N-demethylation. Agents Actions. 1969 Jul;1(1):27–34. doi: 10.1007/BF01990017. [DOI] [PubMed] [Google Scholar]
- Chernozemski I. N., Warwick G. P. Liver regeneration and induction of hepatomas in B6AF mice by urethan. Cancer Res. 1970 Nov;30(11):2685–2690. [PubMed] [Google Scholar]
- Craddock V. M. Induction of liver tumours in rats by a single treatment with nitroso compounds given after partial hepatectomy. Nature. 1973 Oct 19;245(5425):386–389. doi: 10.1038/245386a0. [DOI] [PubMed] [Google Scholar]
- Craddock V. M. Liver carcinomas induced in rats by single administration of dimethylnitrosamine after partial hepatectomy. J Natl Cancer Inst. 1971 Oct;47(4):899–907. [PubMed] [Google Scholar]
- Date P. A., Gothoskar S. V., Bhide S. V. Effect of partial hepatectomy on tumor incidence and metabolism of mice fed thioacetamide. J Natl Cancer Inst. 1976 Mar;56(3):493–497. doi: 10.1093/jnci/56.3.493. [DOI] [PubMed] [Google Scholar]
- Frei J. V., Harsono T. Increased susceptibility to low doses of a carcinogen of epidermal cells in stimulated DNA synthesis. Cancer Res. 1967 Aug;27(8):1482–1484. [PubMed] [Google Scholar]
- Grünthal D., Hellenbroich D. O., Sänger P., Maass H. Der Einfluss von partiellen Hepatektomien auf die Hepatomrate nach Diäthylnitrosamin-Gaben. Z Naturforsch B. 1970 Nov;25(11):1277–1281. [PubMed] [Google Scholar]
- Hard G. C., Butler W. H. Cellular analysis of renal neoplasia: induction of renal tumors in dietary-conditioned rats by dimethylnitrosamine, with a reappraisal of morphological characteristics. Cancer Res. 1970 Nov;30(11):2796–2805. [PubMed] [Google Scholar]
- Hard G. C., Butler W. H. Morphogenesis of epithelial neoplasms induced in the rat kidney by dimethylnitrosamine. Cancer Res. 1971 Oct;31(10):1496–1505. [PubMed] [Google Scholar]
- Henderson P. T., Kersten K. J. Alteration of drug metabolism during rat liver regeneration. Arch Int Pharmacodyn Ther. 1971 Feb;189(2):373–375. [PubMed] [Google Scholar]
- Henderson P. T., Kersten K. J. Metabolism of drugs during rat liver regeneration. Biochem Pharmacol. 1970 Jul;19(7):2343–2351. doi: 10.1016/0006-2952(70)90133-4. [DOI] [PubMed] [Google Scholar]
- Hennings H., Michael D., Patterson E. Enhancement of skin tumorigenesis by a single application of croton oil before or soon after initiation by urethan. Cancer Res. 1973 Dec;33(12):3130–3134. [PubMed] [Google Scholar]
- Hübner K., Voigt H. G. Histoautoradiographische Untersuchungen zur Leberregeneration nach CCl 4 -Vergiftung. Med Welt. 1972 Sep 23;23(39):1348–1351. [PubMed] [Google Scholar]
- Magee P. N., Barnes J. M. Carcinogenic nitroso compounds. Adv Cancer Res. 1967;10:163–246. doi: 10.1016/s0065-230x(08)60079-2. [DOI] [PubMed] [Google Scholar]
- Marquardt H., Sternberg S. S., Philips F. S. 7,12-dimethylbenz(a)anthracene and hepatic neoplasia in regenerating rat liver. Chem Biol Interact. 1970 Dec;2(4):401–403. doi: 10.1016/0009-2797(70)90060-8. [DOI] [PubMed] [Google Scholar]
- McGiven A. R., Ireton H. J. Renal epithelial dysplasia and neoplasia in rats given dimethylnitrosamine. J Pathol. 1972 Nov;108(3):187–190. doi: 10.1002/path.1711080303. [DOI] [PubMed] [Google Scholar]
- Meister P., Rabes H. Nierentumoren durch Diäthylnitrosamin nach partieller Leberresektion: Morphologie und Wachstumsverhalten. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Nov 1;80(2):169–178. doi: 10.1007/BF00305133. [DOI] [PubMed] [Google Scholar]
- O'Connor P. J., Capps M. J., Craig A. W. Comparative studies of the hepatocarcinogen N,N-dimethylnitrosamine in vivo: reaction sites in rat liver DNA and the significance of their relative stabilities. Br J Cancer. 1973 Feb;27(2):153–166. doi: 10.1038/bjc.1973.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Connor P. J., Marigison G. P., Craig A. W. Phosphotriesters in rat liver deoxyribonucleic acid after the administration of the carcinogen NN-dimethylnitrosamine in vivo. Biochem J. 1975 Mar;145(3):475–482. doi: 10.1042/bj1450475. [DOI] [PMC free article] [PubMed] [Google Scholar]
- POUND A. W., WITHERS H. R. THE INFLUENCE OF SOME IRRITANT CHEMICALS AND SCARIFICATION ON TUMOUR INITIATION BY URETHANE IN MICE. Br J Cancer. 1963 Sep;17:460–470. doi: 10.1038/bjc.1963.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pound A. W., Franke F., Lawson T. A. The binding of ethyl carbamate to DNA of mouse liver in vivo: the nature of the bound molecule and the site of binding. Chem Biol Interact. 1976 Jul;14(1-2):149–163. doi: 10.1016/0009-2797(76)90033-8. [DOI] [PubMed] [Google Scholar]
- Pound A. W. Further observations concerning the influence of preliminary stimulation by croton oil and acetic acid on the initiation of skin tumours in mice by urethane. Br J Cancer. 1966 Jun;20(2):385–398. doi: 10.1038/bjc.1966.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pound A. W. Induced cell proliferation and the initiation of skin tumour formation in mice by ultraviolet light. Pathology. 1970 Oct;2(4):269–275. doi: 10.3109/00313027009077141. [DOI] [PubMed] [Google Scholar]
- Pound A. W., Lawson T. A. Effects of partial hepatectomy on carcinogenicity, metabolism, and binding to DNA of ethyl carbamate. J Natl Cancer Inst. 1974 Aug;53(2):423–429. doi: 10.1093/jnci/53.2.423. [DOI] [PubMed] [Google Scholar]
- Pound A. W., Lawson T. A., Horn L. Increased carcinogenic action of dimethylnitrosamine after prior administration of carbon tetrachloride. Br J Cancer. 1973 Jun;27(6):451–459. doi: 10.1038/bjc.1973.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pound A. W., Lawson T. A. Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine. Br J Cancer. 1975 Nov;32(5):596–603. doi: 10.1038/bjc.1975.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pound A. W., Lawson T. A. Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats. Br J Exp Pathol. 1974 Apr;55(2):203–212. [PMC free article] [PubMed] [Google Scholar]
- Pound A. W., Lawson T. A. Protection by carbon tetrachloride against the toxic effects of dimethylnitrosamine in mice. Br J Exp Pathol. 1975 Feb;56(1):77–82. [PMC free article] [PubMed] [Google Scholar]
- Pound A. W. The influence of preliminary irritation by acetic acid or croton oil on skin tumour production in mice after a single application of dimethyl-benzathracene, benzopyrene, or dibenzanthracene. Br J Cancer. 1968 Sep;22(3):533–544. doi: 10.1038/bjc.1968.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rabes H., Hartenstein R., Gminder J. Nierentumoren durch Diaethylnitrosamin bei partiell hepatektomierten Ratten. Naturwissenschaften. 1971 Feb;58(2):102–103. doi: 10.1007/BF00595039. [DOI] [PubMed] [Google Scholar]
- Riopelle J. L., Jasmin G. Nature, classification, and nomenclature of kidney tumors induced in the rat by dimethylnitrosamine. J Natl Cancer Inst. 1969 Apr;42(4):643–662. [PubMed] [Google Scholar]
- Squire R. A., Levitt M. H. Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res. 1975 Nov;35(11 Pt 1):3214–3223. [PubMed] [Google Scholar]




