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. 1978 Feb;37(2):199–212. doi: 10.1038/bjc.1978.28

Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.

J A Houghton, D M Taylor
PMCID: PMC2009589  PMID: 629858

Abstract

The effect of serial passage in immune-deprived mice on certain biological and biochemical parameters has been studied in a series of 6 human colorectal tumour xenografts. Histological integrity is maintained for up to 10 serial passages, together with production of epithelial mucins and carcinoembryonic antigen. Passaged tumours retain human lactate dehydrogenase and glucose-6-phosphate dehydrogenase isoenzyme patterns and a human chromosome constitution. The induction of a murine tumour has been identified in this system, and the importance of routine checks for the presence of human tissue during serial passage is stressed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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