Abstract
Lasiocarpine, a pyrrolizidine alkaloid, was fed at a dietary concentration of 50/10(6) for 55 weeks, to 20 male F-344 rats. Malignant tumours developed in 17/20 animals between 48 and 59 weeks. Forty-five percent (9/20) developed angiosarcomas of the liver and 35% (7/20) had hepatocellular carcinomas. Other tumours included malignant adnexas tumour of the skin (1 rat) and lympohoma (1 rat). Lung metastases were observed in 4 animals with angiosarcoma of the liver and one animal with hepatocellular carcinoma. From one animal, angiosarcoma was successfully transplanted through 4 generations.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Harris P. N., Chen K. K. Development of hepatic tumors in rats following ingestion of Senecio longilobus. Cancer Res. 1970 Dec;30(12):2881–2886. [PubMed] [Google Scholar]
- Jago M. V. The development of the hepatic megalocytosis of chronic pyrrolizidine alkaloid poisoning. Am J Pathol. 1969 Sep;56(3):405–421. [PMC free article] [PubMed] [Google Scholar]
- Reddy J. K., Svoboda D. Effect of lasiocarpine on aflatoxin B 1 carcinogenicity in rat liver. Arch Pathol. 1972 Jan;93(1):55–60. [PubMed] [Google Scholar]
- Rosai J., Sumner H. W., Kostianovsky M., Perez-Mesa C. Angiosarcoma of the skin. A clinicopathologic and fine structural study. Hum Pathol. 1976 Jan;7(1):83–109. doi: 10.1016/s0046-8177(76)80007-x. [DOI] [PubMed] [Google Scholar]
- SCHOENTAL R., HEAD M. A., PEACOCK P. R. Senecio alkaloids; primary liver tumours in rats as a result of treatment with (1) a mixture of alkaloids from S. jacobaea Lin.; (2) retrorsine; (3) isatidine. Br J Cancer. 1954 Sep;8(3):458–465. doi: 10.1038/bjc.1954.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schoental R. Herbal medicines to avoid. Nature. 1972 Jul 14;238(5359):106–107. doi: 10.1038/238106b0. [DOI] [PubMed] [Google Scholar]
- Schoental R. Toxicology and carcinogenic action of pyrrolizidine alkaloids. Cancer Res. 1968 Nov;28(11):2237–2246. [PubMed] [Google Scholar]
- Svoboda D. J., Reddy J. K. Malignant tumors in rats given lasiocarpine. Cancer Res. 1972 May;32(5):908–913. [PubMed] [Google Scholar]
- Toth B. 1,1-Dimethylhydrazine (unsymmetrical) carcinogenesis in mice. Light microscopic and ultrastructural studies on neoplastic blood vessels. J Natl Cancer Inst. 1973 Jan;50(1):181–194. doi: 10.1093/jnci/50.1.181. [DOI] [PubMed] [Google Scholar]