Abstract
Over the past 70 years many experiments have been designed to promote tumour growth. These studies were all carried out in allogeneic tumour systems or by artificially influencing the immunization process. In the present study, the growth of syngeneic mammary tumour cells was enhanced by prior immunization via the intracaecal route. Such induced enhancement could be transferred to untreated animals by serum or by spleen cells. Tumour growth was also enhanced in another syngeneic system by immunization via the intestinal route with frozen-thawed ascites tumour cells. The result is in direct contrast to that obtained by similar immunization with live cells, which affords protection against a later challenge.
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Selected References
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- Attia M. A., Weiss D. W. Immunology of spontaneous mammary carcinomas in mice. V. Acquired tumor resistance and enhancement in strain A mice infected with mammary tumor virus. Cancer Res. 1966 Aug;26(8):1787–1800. [PubMed] [Google Scholar]
- KALISS N. Immunological enhancement of tumor homografts in mice: a review. Cancer Res. 1958 Oct;18(9):992–1003. [PubMed] [Google Scholar]
- KALISS N. Regression or survival of tumor homoiografts in mice pretreated with injections of lyophilized tissues. Cancer Res. 1952 May;12(5):379–382. [PubMed] [Google Scholar]
- LUND H. J. Vaccination of rats against the Yoshida ascites sarcoma with the formation of complement-fixing antibody. Br J Cancer. 1957 Sep;11(3):475–477. doi: 10.1038/bjc.1957.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Laursen M. L., Laursen K. Immunization by the intestinal route of C3H-mice against C3H-L-ascites tumor cells. Proc Soc Exp Biol Med. 1977 Feb;154(2):314–317. doi: 10.3181/00379727-154-39661. [DOI] [PubMed] [Google Scholar]
- MOLLER G. EFFECT ON TUMOUR GROWTH IN SYNGENEIC RECIPIENTS OF ANTIBODIES AGAINST TUMOUR-SPECIFIC ANTIGENS IN METHYLCHOLANTHRENE-INDUCED MOUSE SARCOMAS. Nature. 1964 Nov 28;204:846–847. doi: 10.1038/204846a0. [DOI] [PubMed] [Google Scholar]
- PURDOM L., AMBROSE E. J., KLEIN G. A correlation between electrical surface charge and some biological characteristics during the stepwise progression of a mouse sarcoma. Nature. 1958 Jun 7;181(4623):1586–1587. doi: 10.1038/1811586a0. [DOI] [PubMed] [Google Scholar]
- Ran M., Witz I. P. Tumor-associated immunoglobulins. Enhancement of syngeneic tumors by IgG2-containing tumor eluates. Int J Cancer. 1972 Jan 15;9(1):242–247. doi: 10.1002/ijc.2910090126. [DOI] [PubMed] [Google Scholar]
- Snell G. D. Immunologic enhancement. Surg Gynecol Obstet. 1970 Jun;130(6):1109–1119. [PubMed] [Google Scholar]
- Takasugi M., Hildemann W. H. Lymphocyte-antibody interactions in immunological enhancement. Transplant Proc. 1969 Mar;1(1):530–534. [PubMed] [Google Scholar]