Abstract
For the first time, change in the proton longitudinal relaxation times (T1) of rat tissues has been examined throughout the whole process of azo-dye hepatocarcinogenesis. Two maxima of the T1 values were observed for liver, on Day 60 and after Day 120, and these changes correlated well with the changes in water content. The first peak was ascribed to the immature hepatocytes of hyperplastic nodules, and the second peak to the developed hepatoma cells. The significance of the change in T1 values as a preneoplastic change is discussed.
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Selected References
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- Abelev G. I. Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data. Cancer Res. 1968 Jul;28(7):1344–1350. [PubMed] [Google Scholar]
- Damadian R. Tumor detection by nuclear magnetic resonance. Science. 1971 Mar 19;171(3976):1151–1153. doi: 10.1126/science.171.3976.1151. [DOI] [PubMed] [Google Scholar]
- Damadian R., Zaner K., Hor D., DiMaio T. Human tumors detected by nuclear magnetic resonance. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1471–1473. doi: 10.1073/pnas.71.4.1471. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Endo H., Eguchi M., Yanagi S. Irreversible fixation of increased level of muscle type aldolase activity appearing in rat liver in the early stage of hepatocarcinogenesis. Cancer Res. 1970 Mar;30(3):743–752. [PubMed] [Google Scholar]
- FARBER E. Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3'-methyl-4-dimethylaminoazobenzene. Cancer Res. 1956 Feb;16(2):142–148. [PubMed] [Google Scholar]
- Floyd R. A., Yoshida T., Leigh J. S., Jr Changes of tissue water proton relaxation rates during early phases of chemical carcinogenesis. Proc Natl Acad Sci U S A. 1975 Jan;72(1):56–58. doi: 10.1073/pnas.72.1.56. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hollis D. P., Economou J. S., Parks L. C., Eggleston J. C., Saryan L. A., Czeister J. L. Nuclear magnetic resonance studies of several experimental and human malignant tumors. Cancer Res. 1973 Sep;33(9):2156–2160. [PubMed] [Google Scholar]
- Hollis D. P., Saryan L. A., Economou J. S., Eggleston J. C., Czeisler J. L., Morris H. P. Nuclear magnetic resonance studies of cancer. V. Appearance and development of a tumor systemic effect in serum and tissues. J Natl Cancer Inst. 1974 Sep;53(3):807–815. doi: 10.1093/jnci/53.3.807. [DOI] [PubMed] [Google Scholar]
- Inch W. R., McCredie J. A., Geiger C., Boctor Y. Spin-lattice relaxation times for mixtures of water and gelatin or cotton, compared with normal and malignant tissue. J Natl Cancer Inst. 1974 Sep;53(3):689–690. doi: 10.1093/jnci/53.3.689. [DOI] [PubMed] [Google Scholar]
- Inch W. R., McCredie J. A., Knispel R. R., Thompson R. T., Pintar M. M. Water content and proton spin relaxation time for neoplastic and non-neoplastic tissues from mice and humans. J Natl Cancer Inst. 1974 Feb;52(2):353–356. doi: 10.1093/jnci/52.2.353. [DOI] [PubMed] [Google Scholar]
- Kimelberg H. K., Mayhew E. Increased ouabain-sensitive 86Rb+ uptake and sodium and potassium ion-activated adenosine triphosphatase activity in transformed cell lines. J Biol Chem. 1975 Jan 10;250(1):100–104. [PubMed] [Google Scholar]
- Watabe H. Early appearance of embryonic -globulin in rat serum during carcinogenesis with 4-dimethylaminoazobenzene. Cancer Res. 1971 Sep;31(9):1192–1194. [PubMed] [Google Scholar]