Abstract
Sadler and Castro (1976) reported that a single dose of C. parvum vaccine given i.p. or i.v. to mice 4 days before excision of subcutaneous transplants of Lewis lung carcinoma significantly reduced the incidence of lung metastases in the operated mice. In similarly designed experiments, using 2 different carcinomas of spontaneous origin in our own inbred mouse colonies, we were unable to demonstrate any influence of C. parvum vaccine on the incidence or latent period of secondary disease in operated mice. We discuss possible reasons for our failure to reproduce the findings of Sadler and Castro.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fieldsteel A. H., Dawson P. J., Kurahara C. Tumor-specific transplantation antigens in reticulum cell sarcomas and lymphomas induced by the friend virus complex. Cancer Res. 1973 Mar;33(3):551–558. [PubMed] [Google Scholar]
- Hewitt H. B., Blake E. R. Facilitation of nodal metastasis from a non-immunogenic murine carcinoma by previous whole-body irradiation of tumour recipients. Br J Cancer. 1977 Jul;36(1):23–34. doi: 10.1038/bjc.1977.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hewitt H. B., Blake E. R. Further studies of the relationship between lymphatic dissemination and lymphnodal metastasis in non-immunogenic murine tumours. Br J Cancer. 1977 Apr;35(4):415–419. doi: 10.1038/bjc.1977.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hewitt H. B., Blake E. R., Walder A. S. A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin. Br J Cancer. 1976 Mar;33(3):241–259. doi: 10.1038/bjc.1976.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hewitt H. B. The effect on cell survival of inhalation of oxygen under high pressure during irradiation in vivo of a solid mouse sarcoma. Br J Radiol. 1966 Jan;39(457):19–24. doi: 10.1259/0007-1285-39-457-19. [DOI] [PubMed] [Google Scholar]
- Kobayashi H., Sendo F., Shirai T., Kaji H., Kodama T. Modification in growth of transplantable rat tumors exposed to Friend virus. J Natl Cancer Inst. 1969 Mar;42(3):413–419. [PubMed] [Google Scholar]
- Sadler T. E., Castro J. E. The effects of Corynebacterium parvum and surgery on the Lewis lung carcinoma and its metastases. Br J Surg. 1976 Apr;63(4):292–296. doi: 10.1002/bjs.1800630410. [DOI] [PubMed] [Google Scholar]
- Svet-Moldavsky G. J., Liozner A. L., Mkheidze D. M., Sokolov P. P., Bykovsky A. P. Tumor-induced skin heterogenization. II. Virus causing the phenomenon. J Natl Cancer Inst. 1970 Sep;45(3):475–484. [PubMed] [Google Scholar]