Abstract
The disappearance rate (k) of i.v. glucose was measured in cachectic and non-cachectic cancer patients and tumour-free controls. The respective k values were found to be 1.06 +/- 0.27 (mean +/- s.d.), 1.64 +/- 0.34 and 1.63 +/- 0.23. Of the other parameters measured, only plasma albumin level was found to vary significantly amongst the 3 categories, the mean level being the lowest in cachectic cancer patients. The means of total plasma protein, fasting blood glucose and plasma liver enzyme concentrations were similar in the 3 groups. Glucagon, a potent insulin secretogogue, failed to augment the fasting insulin level in cachectic but did so in non-cachectic cancer patients. Taken together, the findings suggest that the reduced glucose tolerance in patients with neoplasia is due to impairment of insulin release exhibited predominantly by ill-nourished advanced cancer patients having a moderate to sever degree of hypoalbuminemia.
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Selected References
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- Albano J. D., Ekins R. P., Maritz G., Turner R. C. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol (Copenh) 1972 Jul;70(3):487–509. doi: 10.1530/acta.0.0700487. [DOI] [PubMed] [Google Scholar]
- FENNINGER L. D., MIDER G. B. Energy and nitrogen metabolism in cancer. Adv Cancer Res. 1954;2:229–253. doi: 10.1016/s0065-230x(08)60496-0. [DOI] [PubMed] [Google Scholar]
- GLICKSMAN A. S., RAWSON R. W. Diabetes and altered carbohydrate metabolism in patients with cancer. Cancer. 1956 Nov-Dec;9(6):1127–1134. doi: 10.1002/1097-0142(195611/12)9:6<1127::aid-cncr2820090610>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
- Grodsky G. M., Bennett L. L., Smith D. F., Schmid F. G. Effect of pulse administration of glucose or glucagon on insulin secretion in vitro. Metabolism. 1967 Mar;16(3):222–233. doi: 10.1016/0026-0495(67)90171-0. [DOI] [PubMed] [Google Scholar]
- Heard C. R. Effects of severe protein-calorie deficiency on the endocrine control of carbohydrate metabolism. Diabetes. 1966 Feb;15(2):78–89. doi: 10.2337/diab.15.2.78. [DOI] [PubMed] [Google Scholar]
- Holroyde C. P., Gabuzda T. G., Putnam R. C., Paul P., Reichard G. A. Altered glucose metabolism in metastatic carcinoma. Cancer Res. 1975 Dec;35(12):3710–3714. [PubMed] [Google Scholar]
- PEDEN J. C., Jr, BOND L. F., MAXWELL M. Comparative protein repletion in cancer and non-cancer cachexia with special reference to changes in blood volume and total circulating plasma protein and hemoglobin. Am J Clin Nutr. 1957 May-Jun;5(3):305–315. doi: 10.1093/ajcn/5.3.305. [DOI] [PubMed] [Google Scholar]
- SHERMAN C. D., MORTON J. J., MIDER G. B. Potential sources of tumor nitrogen. Cancer Res. 1950 Jun;10(6):374–378. [PubMed] [Google Scholar]
- Smith S. R., Edgar P. J., Pozefsky T., Chhetri M. K., Prout T. E. Insulin secretion and glucose tolerance in adults with protein-calorie malnutrition. Metabolism. 1975 Sep;24(9):1073–1084. doi: 10.1016/0026-0495(75)90101-8. [DOI] [PubMed] [Google Scholar]
- Theologides A. Pathogenesis of cachexia in cancer. A review and a hypothesis. Cancer. 1972 Feb;29(2):484–488. doi: 10.1002/1097-0142(197202)29:2<484::aid-cncr2820290238>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- WATERHOUSE C., FENNINGER L. D., KEUTMANN E. H. Nitrogen exchange and caloric expenditure in patients with malignant neoplasms. Cancer. 1951 May;4(3):500–514. doi: 10.1002/1097-0142(195105)4:3<500::aid-cncr2820040304>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
- WINZLER R. J. Plasma proteins in cancer. Adv Cancer Res. 1953;1:503–548. doi: 10.1016/s0065-230x(08)60010-x. [DOI] [PubMed] [Google Scholar]
- Weinkove C., Weinkove E. A., Pimstone B. L. Glucose tolerance and insulin release in malnourished rats. Clin Sci Mol Med. 1976 Mar;50(3):153–163. doi: 10.1042/cs0500153. [DOI] [PubMed] [Google Scholar]