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. 1978 Aug;38(2):329–334. doi: 10.1038/bjc.1978.206

Inhibition of collagen peptidase in HeLa cells and human tumours by compounds including drugs used in cancer therapy.

W A Boggust, H McGauley
PMCID: PMC2009727  PMID: 212092

Abstract

Collagen-peptidase activity in extracts of HeLa cells and human tumours is inactivated by Razoxane (ICRF-159), cyclophosphamide, 5-fluorouracil, thiotepa, aprotinin, EDTA and phenanthroline. As this activity, in association with other enzymes, may contribute to tissue lysis in cancers, chemical intervention may reduce invasiveness and modify the processes of infiltration and metastasis. Accordingly, some drugs used in therapy or for the prevention of metastasis may produce their observed effects by a combination of factors including enzyme inhibition.

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Selected References

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