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. 1978 Sep;38(3):382–391. doi: 10.1038/bjc.1978.218

Enhancement and metastasis after immunotherapy of ovine squamous-cell carcinoma.

M H Jun, R H Johnson, D J Maguire, P S Hopkins
PMCID: PMC2009732  PMID: 708569

Abstract

Extracts of ovine squamous-cell carcinoma (OSCC) prepared by different procedures, were injected at varying concentrations into 184 tumour-bearing sheep. At a total protein of 0.5 mg and greater, there was significant enhancement and metastasis in all 120 sheep examined. Extracts of OSCC containing less than 0.5 mg protein, or of human squamous-cell carcinoma and normal sheep skin containing high levels of protein, had no effect on subsequent tumour development. Extracts of foetal sheep skin at the 3mg-protein level produced significant enhancement and metastasis. The degree of enhancement was inversely proportional to the developmental stage of the tumour at the time of treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baldwin R. W., Price M. R. Tumor antigens and tumor-host relationships. Annu Rev Med. 1976;27:151–163. doi: 10.1146/annurev.me.27.020176.001055. [DOI] [PubMed] [Google Scholar]
  2. Bluming A. Z. Commentary: Current status of clinical immunotherapy. Cancer Chemother Rep. 1975 Sep-Oct;59(5):901–913. [PubMed] [Google Scholar]
  3. Hughes L. E., Kearney R., Tully M. A study in clinical cancer immunotherapy. Cancer. 1970 Aug;26(2):269–278. doi: 10.1002/1097-0142(197008)26:2<269::aid-cncr2820260205>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  4. KIRBY K. S. A new method for the isolation of deoxyribonucleic acids; evidence on the nature of bonds between deoxyribonucleic acid and protein. Biochem J. 1957 Jul;66(3):495–504. doi: 10.1042/bj0660495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kahan B. D., Pellis N. R. Specific immunoprotection with 3 M KCl solubilized tumor antigen. J Surg Res. 1975 Mar;18(3):263–269. doi: 10.1016/0022-4804(75)90150-x. [DOI] [PubMed] [Google Scholar]
  6. LLOYD L. C. Epithelial tumours of the skin of sheep. Tumours of areas exposed to solar radiation. Br J Cancer. 1961 Dec;15:780–789. doi: 10.1038/bjc.1961.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  8. Ladds P. W., Entwistle K. W. Observations on squamous cell carcinomas of sheep in Queensland, Australia. Br J Cancer. 1977 Jan;35(1):110–114. doi: 10.1038/bjc.1977.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mathé G. Active immunotherapy. Adv Cancer Res. 1971;14:1–36. doi: 10.1016/s0065-230x(08)60517-5. [DOI] [PubMed] [Google Scholar]
  10. Nelson D. S. Immunity to infection, allograft immunity and tumour immunity: parallels and contrasts. Transplant Rev. 1974;19(0):226–254. doi: 10.1111/j.1600-065x.1974.tb00134.x. [DOI] [PubMed] [Google Scholar]
  11. Parr I. Response of syngeneic murine lymphomata to immunotherapy in relation to the antigenicity of the tumour. Br J Cancer. 1972 Jun;26(3):174–182. doi: 10.1038/bjc.1972.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Spradbrow P. B., Wilson B. E., Hoffmann D., Kelly W. R., Francis J. Immunotherapy of bovine ocular squamous cell carcinomas. Vet Rec. 1977 Apr 30;100(18):376–378. doi: 10.1136/vr.100.18.376. [DOI] [PubMed] [Google Scholar]
  13. Symes M. O. Tumour immunology. Br J Surg. 1974 Dec;61(12):929–938. doi: 10.1002/bjs.1800611202. [DOI] [PubMed] [Google Scholar]
  14. Van Kampen K. R., Crisp W. E., De Martini J. C., Ellsworth H. S. The immunologic therapy of squamous cell carcinoma. A preliminary report. Am J Obstet Gynecol. 1973 Jun 15;116(4):569–574. doi: 10.1016/0002-9378(73)90916-2. [DOI] [PubMed] [Google Scholar]
  15. WOODRUFF M. F. IMMUNOLOGICAL ASPECTS OF CANCER. Lancet. 1964 Aug 8;2(7354):265–270. doi: 10.1016/s0140-6736(64)93042-9. [DOI] [PubMed] [Google Scholar]

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