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. 1978 Oct;38(4):496–502. doi: 10.1038/bjc.1978.236

Chemical modification and immunogenicity of membrane fractions from mouse tumour cells.

H J Staab, F A Anderer
PMCID: PMC2009756  PMID: 215180

Abstract

A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with a membrane sample modified with dimethylsulphate. Up to 60% of the animals remained tumour free, and the tumour-bearing animals showed a greatly increased mean survival time. The post-challenge sera contained no detectable amounts of cytotoxic antibodies. The membrane sample isolated from tumour cells which had been modified with dimethylsulphate showed less immunogenicity than the modified cells or the membrane fraction from unmodified cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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