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. 1979 May;39(5):578–583. doi: 10.1038/bjc.1979.104

A human testicular teratoma serially transplanted in immune-deprived mice.

P J Selby, E Heyderman, J Gibbs, M J Peckham
PMCID: PMC2009907  PMID: 385030

Abstract

Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is concluded that the xenograft retained the characteristics of the original tumour with the exception of a reduction in HCG-producing elements at transplantation beyond 5 serial passages.

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Selected References

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  1. Berenbaum M. C., Sheard C. E., Reittie J. R., Bundick R. V. The growth of human tumours in immunosuppressed mice and their response to chemotherapy. Br J Cancer. 1974 Jul;30(1):13–32. doi: 10.1038/bjc.1974.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Giovanella B. C., Stehlin J. S., Williams L. J., Jr Heterotransplantation of human malignant tumors in "nude" thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumors. J Natl Cancer Inst. 1974 Mar;52(3):921–930. doi: 10.1093/jnci/52.3.921. [DOI] [PubMed] [Google Scholar]
  3. Heyderman E., Neville A. M. Letter: Syncytiotrophoblasts in malignant testicular tumours. Lancet. 1976 Jul 10;2(7976):103–103. doi: 10.1016/s0140-6736(76)92325-4. [DOI] [PubMed] [Google Scholar]
  4. Houghton J. A., Taylor D. M. Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice. Br J Cancer. 1978 Feb;37(2):199–212. doi: 10.1038/bjc.1978.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lamerton L. F., Steel G. G. Growth kinetics of human large bowel cancer growing in immune-deprived mice and some chemotherapeutic observations. Cancer. 1975 Dec;36(6 Suppl):2431–2436. doi: 10.1002/1097-0142(197512)36:6<2431::aid-cncr2820360625>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  6. Millar J. L., Blackett N. M., Hudspith B. N. Enhanced post-irradiation recovery of the haemopoietic system in animals pretreated with a variety of cytotoxic agents. Cell Tissue Kinet. 1978 Sep;11(5):543–553. doi: 10.1111/j.1365-2184.1978.tb00826.x. [DOI] [PubMed] [Google Scholar]
  7. Nakane P. K., Kawaoi A. Peroxidase-labeled antibody. A new method of conjugation. J Histochem Cytochem. 1974 Dec;22(12):1084–1091. doi: 10.1177/22.12.1084. [DOI] [PubMed] [Google Scholar]
  8. Steel G. G., Courtenay V. D., Rostom A. Y. Improved immune-suppression techniques for the exongrafting of human tumours. Br J Cancer. 1978 Feb;37(2):224–230. doi: 10.1038/bjc.1978.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. VERNEY E. L., PIERCE G. B., DIXON F. J., Jr The biology of testicular cancer. III. Heterotransplanted choriocarcinomas. Cancer Res. 1959 Jul;19(6 Pt 1):633–637. [PubMed] [Google Scholar]
  10. Vaitukaitis J. L., Braunstein G. D., Ross G. T. A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. Am J Obstet Gynecol. 1972 Jul 15;113(6):751–758. doi: 10.1016/0002-9378(72)90553-4. [DOI] [PubMed] [Google Scholar]

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