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. 1979 Jun;39(6):667–675. doi: 10.1038/bjc.1979.118

Antibody-dependent and spontaneous lympholysis in urologic cancer patients.

T L Ratliff, R E McCool, W J Catalona
PMCID: PMC2009983  PMID: 444405

Abstract

To evaluate cytotoxic function mediated by killer lymphocytes and macrophages in urological cancer patients, we examined antibody-dependent and spontaneous lympholysis of chicken erythrocyte target cells, which is mediated by macrophages. Our results demonstrate a discordance between cytotoxic mechanisms in cancer patients, killer-cell function being impaired whilst macrophage-mediated cytotoxicity was increased.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brier A. M., Chess L., Schlossman S. F. Human antibody-dependent cellular cytotoxicity. Isolation and identification of a subpopulation of peripheral blood lymphocytes which kill antibody-coated autologous target cells. J Clin Invest. 1975 Dec;56(6):1580–1586. doi: 10.1172/JCI108240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Catalona W. J., Ratliff T. L., McCool R. E. Effects of carrageenan on spontaneous and antibody-dependent cell-mediated cytotoxicity. Cell Immunol. 1978 Sep 15;40(1):1–15. doi: 10.1016/0008-8749(78)90310-6. [DOI] [PubMed] [Google Scholar]
  3. Eremin O., Ashby J., Franks D. Killer cell (K) activity in human normal lymph node, regional tumour lymph node and inflammatory lymph node. Int Arch Allergy Appl Immunol. 1977;54(3):210–220. doi: 10.1159/000231829. [DOI] [PubMed] [Google Scholar]
  4. Hakala T. R., Lange P. H., Castro A. E., Elliott A. Y., Fraley E. E. Antibody induction of lymphocyte-mediated cytotoxicity against human transitional-cell carcinomas of the urinary tract. N Engl J Med. 1974 Sep 26;291(13):637–641. doi: 10.1056/NEJM197409262911301. [DOI] [PubMed] [Google Scholar]
  5. Herberman R. B., Nunn M. E., Holden H. T., Lavrin D. H. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int J Cancer. 1975 Aug 15;16(2):230–239. doi: 10.1002/ijc.2910160205. [DOI] [PubMed] [Google Scholar]
  6. Kiessling R., Petranyi G., Kärre K., Jondal M., Tracey D., Wigzell H. Killer cells: a functional comparison between natural, immune T-cell and antibody-dependent in vitro systems. J Exp Med. 1976 Apr 1;143(4):772–780. doi: 10.1084/jem.143.4.772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MacDonald H. R., Bonnard G. D., Sordat B., Zawodnik S. A. Antibody-dependent cell-mediated cytotoxicity: heterogeneity of effector cells in human peripheral blood. Scand J Immunol. 1975 Sep;4(5-6):487–497. doi: 10.1111/j.1365-3083.1975.tb02654.x. [DOI] [PubMed] [Google Scholar]
  8. Mantovani B., Rabinovitch M., Nussenzweig V. Phagocytosis of immune complexes by macrophages. Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG). J Exp Med. 1972 Apr 1;135(4):780–792. doi: 10.1084/jem.135.4.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nelson D. L., Bundy B. M., Pitchon H. E., Blaese R. M., Strober W. The effector cells in human peripheral blood mediating mitogen-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity. J Immunol. 1976 Nov;117(5 Pt 1):1472–1481. [PubMed] [Google Scholar]
  10. O'Toole C., Saxon A., Bohrer R. Human lymph node lymphocytes fail to effect lysis of antibody-coated target cells. Clin Exp Immunol. 1977 Jan;27(1):165–171. [PMC free article] [PubMed] [Google Scholar]
  11. Pape G. R., Troye M., Perlmann P. Characterization of cytolytic effector cells in peripheral blood of healthy individuals and cancer patients. II. Cytotoxicity to allogeneic or autochthonous tumor cells in tissue culture. J Immunol. 1977 Jun;118(6):1925–1930. [PubMed] [Google Scholar]
  12. Perlmann P., Perlmann H., Larsson A., Wåhlin B. Antibody dependent cytolytic effector lymphocytes (K cells) in human blood. J Reticuloendothel Soc. 1975 Apr;17(4):241–250. [PubMed] [Google Scholar]
  13. Peter H. H., Pavie-Fischer J., Fridman W. H., Aubert C., Cesarini J. P., Roubin R., Kourilsky F. M. Cell-mediate cytotoxicity in vitro of human lymphocytes against a tissue culture melanoma cell line (igr3). J Immunol. 1975 Aug;115(2):539–548. [PubMed] [Google Scholar]
  14. Pross H. F., Baines M. G. Spontaneous human lymphocyte-mediated cytotoxicity againts tumour target cells. I. The effect of malignant disease. Int J Cancer. 1976 Nov 15;18(5):593–604. doi: 10.1002/ijc.2910180508. [DOI] [PubMed] [Google Scholar]
  15. Rhodes J. Altered expression of human monocyte Fc receptors in malignant disease. Nature. 1977 Jan 20;265(5591):253–255. doi: 10.1038/265253a0. [DOI] [PubMed] [Google Scholar]
  16. Stratton M. L., Herz J., Loeffler R. A., McClurg F. L., Reiter A., Bernstein P., Danley D. L., Benjamini E. Antibody-dependent cell-mediated cytotoxicity in treated and nontreated cancer patients. Cancer. 1977 Sep;40(3):1045–1051. doi: 10.1002/1097-0142(197709)40:3<1045::aid-cncr2820400312>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  17. Takasugi M., Mickey M. R., Terasaki P. I. Reactivity of lymphocytes from normal persons on cultured tumor cells. Cancer Res. 1973 Nov;33(11):2898–2902. [PubMed] [Google Scholar]
  18. Takasugi M., Ramseyer A., Takasugi J. Decline of natural nonselective cell-mediated cytotoxicity in patients with tumor progression. Cancer Res. 1977 Feb;37(2):413–418. [PubMed] [Google Scholar]
  19. Ting A., Terasaki P. I. Depressed lymphocyte-mediated killing of sensitized targets in cancer patients. Cancer Res. 1974 Oct;34(10):2694–2698. [PubMed] [Google Scholar]
  20. Troye M., Perlmann P., Larsson A., Blomgren H., Johansson B. Cellular cytotoxicity in vitro in transitional cell carcinoma of the human urinary bladder: 51Cr-release assay. Int J Cancer. 1977 Aug 15;20(2):188–198. doi: 10.1002/ijc.2910200205. [DOI] [PubMed] [Google Scholar]
  21. West W. H., Boozer R. B., Herberman R. B. Low affinity E-rosette formation by the human K cell. J Immunol. 1978 Jan;120(1):90–95. [PubMed] [Google Scholar]

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