Abstract
In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenols gave an approximately 6-fold increase in the risk for this type of tumour. It was not possible to determine, however, whether the carcinogenic effect was exerted by these compounds or by impurities such as chlorinated dibenzodioxins and dibenzofurans that in almost all cases were part of the commercial preparations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Axelson O., Sundell L. Herbicide exposure, mortality and tumor incidence. An epidemiological investigation on Swedish railroad workers. Work Environ Health. 1974;11(1):21–28. [PubMed] [Google Scholar]
- Levin J. O., Rappe C., Nilsson C. A. Use of chlorophenols as fungicides in sawmills. Scand J Work Environ Health. 1976 Jun;2(2):71–81. doi: 10.5271/sjweh.2816. [DOI] [PubMed] [Google Scholar]
- Miettinen O. S. Components of the crude risk ratio. Am J Epidemiol. 1972 Aug;96(2):168–172. doi: 10.1093/oxfordjournals.aje.a121443. [DOI] [PubMed] [Google Scholar]
- Miettinen O. S. Estimation of relative risk from individually matched series. Biometrics. 1970 Mar;26(1):75–86. [PubMed] [Google Scholar]
- Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
- Muranyi-Kovacs I., Rudali G., Imbert J. Bioassay of 2, 4, 5-trichlorophenoxyacetic acid for carcinogenicity in mice. Br J Cancer. 1976 Jun;33(6):626–633. doi: 10.1038/bjc.1976.100. [DOI] [PMC free article] [PubMed] [Google Scholar]