Abstract
During a population-based screening project for breast cancer, almost 15,000 women aged 50 years and over have provided a 12 h (overnight) sample of urine for research purposes. In 3,789 women the excretion of 11-desoxy-17-oxosteroids (DOOS) and creatinine was measured. Results were analysed in terms of urinary concentrations and of a ratio between DOOS and creatinine. Age had an effect on DOOS, creatinine and their ratio. Body weight and body surface area had an effect on creatinine excretion and therefore on the ratio. The following variables did not have an appreciable effect on the above-mentioned ratio: a family history of breast cancer, parity and age at first pregnancy, menopause and oestrogenic drugs, and parenchymal pattern of the breast as observed on the xeromammogram. Breast cancer was found at first screening in 106 out of 14,697 women. In 100 of these cases DOOS and creatinine were measured. Excretion values expressed as the ratio between the two, allowing for body surface area, did not differ materially from those of 100 age-matched controls. These results lead the authors to the conclusion that the determination of androgen metabolite excretion in women over 50 years of age is of no help in selecting a group at high risk of breast cancer.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BULBROOK R. D., HAYWARD J. L., SPICER C. C., THOMAS B. S. A comparison between the urinary steroid excretion of normal women and women with advanced breast cancer. Lancet. 1962 Dec 15;2(7268):1235–1237. doi: 10.1016/s0140-6736(62)92811-8. [DOI] [PubMed] [Google Scholar]
- Bulbrook R. D., Hayward J. L. Excretion of urinary 17-hydroxycorticosteroids and 11-deoxy-17-oxosteroids by women using steroidal contraceptives. Lancet. 1969 Nov 15;2(7629):1033–1035. doi: 10.1016/s0140-6736(69)90642-4. [DOI] [PubMed] [Google Scholar]
- Bulbrook R. D., Hayward J. L., Spicer C. C. Relation between urinary androgen and corticoid excretion and subsequent breast cancer. Lancet. 1971 Aug 21;2(7721):395–398. doi: 10.1016/s0140-6736(71)90113-9. [DOI] [PubMed] [Google Scholar]
- DE WAARD F., BAANDERS-VANHALEWIJN E. A., HUIZINGA J. THE BIMODAL AGE DISTRIBUTION OF PATIENTS WITH MAMMARY CARCINOMA; EVIDENCE FOR THE EXISTENCE OF 2 TYPES OF HUMAN BREAST CANCER. Cancer. 1964 Feb;17:141–151. doi: 10.1002/1097-0142(196402)17:2<141::aid-cncr2820170202>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
- Farewell V. T. The combined effect of breast cancer risk factors. Cancer. 1977 Aug;40(2):931–936. doi: 10.1002/1097-0142(197708)40:2<931::aid-cncr2820400251>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
- Gehan E. A., George S. L. Estimation of human body surface area from height and weight. Cancer Chemother Rep. 1970 Aug;54(4):225–235. [PubMed] [Google Scholar]
- Miller H., Durant J. A., Jacobs A. G., Allison J. F. Alternative discriminating function for determining hormone dependency of breast cancer. Br Med J. 1967 Jan 21;1(5533):147–149. doi: 10.1136/bmj.1.5533.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rademaker B., Jongejan-Timmer A., Poortman J., Thijssen J. H. A semiautomated method for the determination of 11-deoxy-17-oxo-steroids in urine. Clin Chim Acta. 1976 Aug 2;70(3):349–356. doi: 10.1016/0009-8981(76)90347-8. [DOI] [PubMed] [Google Scholar]
- Shapiro S., Strax P., Venet L. Periodic breast cancer screening in reducing mortality from breast cancer. JAMA. 1971 Mar 15;215(11):1777–1785. [PubMed] [Google Scholar]
- Vestergaard P. Excretion of common neutral steroids in healthy subjects as estimated by multi-column chromatography. Acta Endocrinol Suppl (Copenh) 1978;217:157–189. [PubMed] [Google Scholar]
- Wolfe J. N. Risk for breast cancer development determined by mammographic parenchymal pattern. Cancer. 1976 May;37(5):2486–2492. doi: 10.1002/1097-0142(197605)37:5<2486::aid-cncr2820370542>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]