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. 1979 Aug;40(2):268–273. doi: 10.1038/bjc.1979.175

Effects of progesterone on mammary carcinogenesis by DMBA applied directly to rat mammae.

A G Jabara, G N Marks, J E Summers, P S Anderson
PMCID: PMC2010010  PMID: 113024

Abstract

The effects and site(s) of action of progesterone on DMBA mammary carcinogenesis in the rat, when a small dose of the carcinogen was applied directly to the inguinal mammary gland, were investigated. No reduction in tumour yield was apparent when progesterone was administered s.c. for 18 days before dusting DMBA. This finding contrasts with a previously reported inhibitory effect on carcinogenesis when hormone treatment was followed by intragastric administration of DMBA. When progesterone injections were begun either 2 days before or 2 days after direct application of DMBA, and were continued until the end of the experiment (135 or 195 days) an enhancement in carcinogenesis was observed similar to that previously demonstrated after gastric intubation of DMBA. These findings, together with previously reported observations, suggest that progesterone may exert its inhibitory effect on carcinogenesis by acting at a site outside the breast, perhaps on the liver. However, it is likely that the hormone acts directly on the mammary tissue to exert its enhancing effect on tumorigenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CEFIS F., GOODALL C. M. DISTRIBUTION AND SPECIES LIMITATION OF THE ADRENAL LESIONS INDUCED BY 7,12-DIMETHYLBENZ(A)ANTHRACENE. Am J Pathol. 1965 Feb;46:227–243. [PMC free article] [PubMed] [Google Scholar]
  2. Dao T. L. Inhibition of tumor induction in chemical carcinogenesis in the mammary gland. Prog Exp Tumor Res. 1971;14:59–88. doi: 10.1159/000392271. [DOI] [PubMed] [Google Scholar]
  3. Dao T. L., King C. L., Gawlak D. Mammary gland transplantation and tumorigenesis. I. Concentration and clearance of 7,12-dimethylbenz[a]anthracene in the graft. J Natl Cancer Inst. 1968 Jan;40(1):157–164. [PubMed] [Google Scholar]
  4. DePierre J. W., Ernster L. The metabolism of polycyclic hydrocarbons and its relationship to cancer. Biochim Biophys Acta. 1978 Apr 6;473(3-4):149–186. doi: 10.1016/0304-419x(78)90013-6. [DOI] [PubMed] [Google Scholar]
  5. Feuer G., Kellen J. A. Inhibition and enhancement of mammary tumorigenesis by 7,12-dimethylbenz (a) anthracene in the female sprague-dawley rat. Int J Clin Pharmacol. 1974 Jan;9(1):62–69. [PubMed] [Google Scholar]
  6. Feuer G., Kellen J. A. Link between carcinogenicity and hepatic metabolism of 7,12-dimethylbenz(alpha)anthracene. Oncology. 1974;30(6):499–508. doi: 10.1159/000224994. [DOI] [PubMed] [Google Scholar]
  7. Flesher J. W. Distribution of radioactivity in the tissues of rats after oral administration of 7,12-dimethylbenz(A)anthracene-3H. Biochem Pharmacol. 1967 Sep 9;16(9):1821–1831. doi: 10.1016/0006-2952(67)90259-6. [DOI] [PubMed] [Google Scholar]
  8. Gammal E. B., Carroll K. K., Muhlstock B. H., Plunkett E. R. Quantitative estimation of 7,12-dimethylbenz(a)anthracene in rat mammary tissue by gas liquid chromatography. Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1086–1089. doi: 10.3181/00379727-119-30383. [DOI] [PubMed] [Google Scholar]
  9. HUGGINS C., MORII S. Selective adrenal necrosis and apoplexy induced by 7, 12-dimethylbenz(a)anthracene. J Exp Med. 1961 Nov 1;114:741–760. doi: 10.1084/jem.114.5.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jabara A. G. Effects of progesterone on 9,10-dimethyl-1,2-benzanthracene-induced mammary tumours in Sprague-Dawley rats. Br J Cancer. 1967 Jun;21(2):418–429. doi: 10.1038/bjc.1967.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jabara A. G., Harcourt A. G. The effects of progesterone and ovariectomy on mammary tumours induced by 7,1 2-dimethylbenz(a)anthracene in Sprague-Dawley rats. Pathology. 1970 Apr;2(2):115–123. doi: 10.3109/00313027009077333. [DOI] [PubMed] [Google Scholar]
  12. Jabara A. G., Toyne P. H., Fisher R. J. An autoradiographic study of the early effects of 7,12-dimethylbenz(a)anthracene and progesterone on DNA synthesis in rat mammary epithelial cells and subsequent tumour development. Br J Cancer. 1972 Aug;26(4):265–273. doi: 10.1038/bjc.1972.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jabara A. G., Toyne P. H., Harcourt A. G. Effects of time and duration of progesterone administration on mammary tumours induced by 7,12-dimethylbenz(a)anthracene in Sprague-Dawley rats. Br J Cancer. 1973 Jan;27(1):63–71. doi: 10.1038/bjc.1973.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Peto R., Pike M. C. Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data. Biometrics. 1973 Sep;29(3):579–584. [PubMed] [Google Scholar]
  15. Sinha D., Dao T. L. A direct mechanism of mammary carcinogenesis induced by 7,12-dimethyl-benz(alpha)anthracene. J Natl Cancer Inst. 1974 Sep;53(3):841–846. doi: 10.1093/jnci/53.3.841. [DOI] [PubMed] [Google Scholar]
  16. Welsch C. W., Clemens J. A., Meites J. Effects of multiple pituitary homografts or progesterone on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in rats. J Natl Cancer Inst. 1968 Aug;41(2):465–471. [PubMed] [Google Scholar]

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