Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1979 Aug;40(2):253–259. doi: 10.1038/bjc.1979.173

Tissue distribution and biochemical properties of an interspecific tumour-associated gamma foetal antigen.

P J Higgins, C Tong, E Borenfreund, R S Okin, A Bendich
PMCID: PMC2010012  PMID: 475970

Abstract

A late-gestation neonatal antigen (gamma foetal antigen; gamma-FA) immunologically and biochemically unrelated to murine alpha-foetoprotein, was identified in several spontaneous and carcinogen-induced sarcomas and hepatic carcinomas of the mouse and rat. An approximate mol. wt of 35,000 for gamma-FA from both foetus and tumour was obtained by molecular-sieve chromatography and sucrose-gradient centrifugation. Radial immunodiffusion analyses of organ extracts indicated that gamma-FA could be found in several neonatal tissues, the highest concentration occurring in the spleen. In the 2-month-old mouse, only splenic tissue contained gamma-FA and at much lower levels than in the organ of the newborn mouse.

Full text

PDF
253

Images in this article

255Fig. 1
on p.255
258Fig. 4
on p.258

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACKERS G. K. MOLECULAR EXCLUSION AND RESTRICTED DIFFUSION PROCESSES IN MOLECULAR-SIEVE CHROMATOGRAPHY. Biochemistry. 1964 May;3:723–730. doi: 10.1021/bi00893a021. [DOI] [PubMed] [Google Scholar]
  2. Baldwin R. W., Embleton M. J. Neoantigens on spontaneous and carcinogen-induced rat tumors defined by in vitro lymphocytotoxicity assays. Int J Cancer. 1974 Apr 15;13(4):433–443. doi: 10.1002/ijc.2910130402. [DOI] [PubMed] [Google Scholar]
  3. Borenfreund E., Bendich A. In vitro demonstration of Mallory body formation in liver cells from rats fed diethylnitrosamine. Lab Invest. 1978 Mar;38(3):295–303. [PubMed] [Google Scholar]
  4. Borenfreund E., Higgins P. J., Bendich A. In vivo initiated rat liver carcinogenesis studied in vitro; formation of alcoholic hyaline-type bodies. Cancer Lett. 1977 Sep;3(3-4):145–150. doi: 10.1016/s0304-3835(77)95126-6. [DOI] [PubMed] [Google Scholar]
  5. Coggin J. H., Jr, Anderson N. G. Cancer, differentiation and embryonic antigens: some central problems. Adv Cancer Res. 1974;19(0):105–165. doi: 10.1016/s0065-230x(08)60053-6. [DOI] [PubMed] [Google Scholar]
  6. Higgins P. J., Tong C., Borenfreund E., Bendich A. Differential association of fetal antigen with hepatoma tissue grown in vivo and in vitro. Eur J Cancer. 1979 Apr;15(4):423–431. doi: 10.1016/0014-2964(79)90077-x. [DOI] [PubMed] [Google Scholar]
  7. Ishimoto A., Suzuki Y., Yoshida T., Ito Y. Further studies on mouse fetal antigen cross-reactive with Rauscher leukemia. Cancer Res. 1974 Sep;34(9):2338–2343. [PubMed] [Google Scholar]
  8. Lardinois R., Page L. A. Serum albumin, prealbumin, and postalbumin in perinatal pigs. Dev Biol. 1969 Mar;19(3):261–280. doi: 10.1016/0012-1606(69)90064-5. [DOI] [PubMed] [Google Scholar]
  9. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  10. OLD L. J., BOYSE E. A. IMMUNOLOGY OF EXPERIMENTAL TUMORS. Annu Rev Med. 1964;15:167–186. doi: 10.1146/annurev.me.15.020164.001123. [DOI] [PubMed] [Google Scholar]
  11. PREHN R. T., MAIN J. M. Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst. 1957 Jun;18(6):769–778. [PubMed] [Google Scholar]
  12. Parker G. A., Rosenberg S. A. Cross-reacting antigens in chemically induced sarcomas are fetal determinants. J Immunol. 1977 May;118(5):1590–1594. [PubMed] [Google Scholar]
  13. Parker G. A., Rosenberg S. A. Serologic identification of multiple tumor-associated antigens on murine sarcomas. J Natl Cancer Inst. 1977 May;58(5):1303–1309. doi: 10.1093/jnci/58.5.1303. [DOI] [PubMed] [Google Scholar]
  14. Prehn R. T. Cancer antigens in tumors induced by chemicals. Fed Proc. 1965 Sep-Oct;24(5):1018–1022. [PubMed] [Google Scholar]
  15. Reiner J., Southam C. M. Evidence of common antigenic properties in chemically induced sarcomas of mice. Cancer Res. 1967 Jul;27(7):1243–1247. [PubMed] [Google Scholar]
  16. Sherman M. R. Physical-chemical analysis of steroid hormone receptors. Methods Enzymol. 1975;36:211–234. doi: 10.1016/s0076-6879(75)36021-7. [DOI] [PubMed] [Google Scholar]
  17. Stonehill E. H., Bendich A. Retrogenetic expression: the reappearance of embryonal antigens in cancer cells. Nature. 1970 Oct 24;228(5269):370–372. doi: 10.1038/228370a0. [DOI] [PubMed] [Google Scholar]
  18. Tong C., Stonehill E. H., Higgins P. J., Bendich A. A fetal antigen in a mouse fibrosarcoma with possible cross-reactivity with an adult mouse skin component. Eur J Cancer. 1978 Feb;14(2):147–152. doi: 10.1016/0014-2964(78)90173-1. [DOI] [PubMed] [Google Scholar]
  19. Zimmerman E. F., Bowen D., Wilson J. R., Madappally M. M. Developmental microheterogeneity of mouse alpha-fetoproteins: purification and partial characterization. Biochemistry. 1976 Dec 14;15(25):5534–5543. doi: 10.1021/bi00670a018. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES