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. 1979 Aug;40(2):260–267. doi: 10.1038/bjc.1979.174

Effects of discontinuation of chronic feeding of diethylnitrosamine on the development of hepatomas in adult rats.

H Barbason, V Smoliar, A Fridman-Manduzio, E H Betz
PMCID: PMC2010017  PMID: 475971

Abstract

Diethylnitrosamine (DENA) at 10 mg/kg was fed to adult rats either continuously or for periods ranging from 1 to 10 weeks. Survival correlated inversely with the duration of carcinogen feeding. Less than 4 weeks of DENA feeding produced only preneoplastic foci that persisted indefinitely; 4 weeks were found to be necessary for the transformation of preneoplastic lesions into liver cancers; after 6 weeks, the incidence of hepatomas was 100%. The process of liver cancerization appeared to be identical whether DENA was fed for 8 weeks or continuously up to the time of death. These results are discussed in the light of the evolution of the homoeostatic control of liver-cell division during DENA feeding, in order to distinguish the different successive roles played by the carcinogen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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