Abstract
The modal DNA values of 1465 tumours, together with other factors of possible prognostic importance, were related to the survival of the patients, using regression models (Kay, 1977). For most tumour sites except the testis, the distributions of modal DNA values were bimodal, with peaks at the diploid level and in the triploid-tetraploid range. For all tumour sites except the cervix uteri, patients in the low (near-diploid) range showed better survival; the reverse was true for squamous-cell carcinoma of the cervix uteri. Other variables showed the following effects: for all sites except the testis, younger patients showed a better survival; for the cervix and corpus uteri, breast and ovary, increasing clinical stage was associated with poorer survival. Where evaluated, histological grade appeared to be associated with survival rate, the less well differentiated tumours having a worse prognosis, except for the breast, where the reverse correlation was noted. For carcinoma of the bladder, females and a poorer survival rate than males.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ATKIN N. B., RICHARDS B. M. Clinical significance of ploidy in carcinoma of cervix: its relation to prognosis. Br Med J. 1962 Dec 1;2(5317):1445–1446. doi: 10.1136/bmj.2.5317.1445. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ATKIN N. B., RICHARDS B. M. Deoxyribonucleic acid in human tumours as measured by microspectrophotometry of Feulgen stain: a comparison of tumours arising at different sites. Br J Cancer. 1956 Dec;10(4):769–786. doi: 10.1038/bjc.1956.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Atkin N. B. High chromosome numbers of seminomata and malignant teratomata of the testis: a review of data on 103 tumours. Br J Cancer. 1973 Sep;28(3):275–279. doi: 10.1038/bjc.1973.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Atkin N. B., Mattinson G., Baker M. C. A comparison of the DNA content and chromosome number of fifty human tumours. Br J Cancer. 1966 Mar;20(1):87–101. doi: 10.1038/bjc.1966.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Atkin N. B. Modal DNA value and chromosome number in ovarian neoplasia. A clinical and histopathologic assessment. Cancer. 1971 May;27(5):1064–1073. doi: 10.1002/1097-0142(197105)27:5<1064::aid-cncr2820270510>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
- Atkin N. B. Modal deoxyribonucleic acid value and survival in carcinoma of the breast. Br Med J. 1972 Jan 29;1(5795):271–272. doi: 10.1136/bmj.1.5795.271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Atkin N. B. Prognostic significance of ploidy level in human tumors. I. Carcinoma of the uterus. J Natl Cancer Inst. 1976 May;56(5):909–910. doi: 10.1093/jnci/56.5.909. [DOI] [PubMed] [Google Scholar]
- Atkin N. B. Prognostic significance of ploidy level in human tumours. II extra-uterine cancers and summary of data on 1171 tumours. Cytobios. 1976;15(60):233–237. [PubMed] [Google Scholar]
- Tavares A. S., Costa J., de Carvalho A., Reis M. Tumour ploidy and prognosis in carcinomas of the bladder and prostate. Br J Cancer. 1966 Sep;20(3):438–441. doi: 10.1038/bjc.1966.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams J. S. Efficient analysis of Weibull survival data from experiments on heterogeneous patient populations. Biometrics. 1978 Jun;34(2):209–222. [PubMed] [Google Scholar]