Abstract
The cumulative radiation effect (CRE) is one of several empirical scalar descriptions of biological effect which enable corrections to be made for gaps in radiotherapy treatment. Predictions of this theory were tested using mouse crypt regeneration and mouse skin as biological models. These experimental results are discussed in terms of the dependence of tissue regeneration potential during a gap on the biological effect achieved before the gap, and on gap length. A hypothesis is proposed to reconcile the apparent conflict between the two experiments. While the simple exponential gap formulation of the CRE is seen to be inadequate, insufficient data are available at present to modify it.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown J. M., Probert J. C. Early and late radiation changes following a second course of irradiation. Radiology. 1975 Jun;115(3):711–716. doi: 10.1148/15.3.711. [DOI] [PubMed] [Google Scholar]
- Cohen L. A cell population kinetic model for fractionated radiation therapy. I. Normal tissues. Radiology. 1971 Nov;101(2):419–427. doi: 10.1148/101.2.419. [DOI] [PubMed] [Google Scholar]
- Denekamp J. Changes in the rate of repopulation during multifraction irradiation of mouse skin. Br J Radiol. 1973 May;46(545):381–387. doi: 10.1259/0007-1285-46-545-381. [DOI] [PubMed] [Google Scholar]
- Hamlet R., Carr K. E., Toner P. G., Nias A. H. Scanning electron microscopy of mouse intestinal mucosa after cobalt 60 and D-T neutron irradiation. Br J Radiol. 1976 Jul;49(583):624–629. doi: 10.1259/0007-1285-49-583-624. [DOI] [PubMed] [Google Scholar]
- Hendry J. H., Rosenberg I., Greene D., Stewart J. G. Re-irradiation of rat tails to necrosis at six months after treatment with a "tolerance" dose of x rays or neutrons. Br J Radiol. 1977 Aug;50(596):567–572. doi: 10.1259/0007-1285-50-596-567. [DOI] [PubMed] [Google Scholar]
- Hunter R. D., Stewart J. G. The tolerance of re-irradiation of heavily irradiated human skin. Br J Radiol. 1977 Aug;50(596):573–575. doi: 10.1259/0007-1285-50-596-573. [DOI] [PubMed] [Google Scholar]
- Kirk J., Gray W. M., Watson E. R. Cumulative radiation effect. I. Fractionated treatment regimes. Clin Radiol. 1971 Apr;22(2):145–155. doi: 10.1016/s0009-9260(71)80044-2. [DOI] [PubMed] [Google Scholar]
- Kirk J., Gray W. M., Watson E. R. Cumulative radiation effect. Part VI: simple nomographic and tabular methods for the solution of practical problems. Clin Radiol. 1977 Jan;28(1):29–74. doi: 10.1016/s0009-9260(77)80132-3. [DOI] [PubMed] [Google Scholar]
- Orton C. G., Ellis F. A simplification in the use of the NSD concept in practical radiotherapy. Br J Radiol. 1973 Jul;46(547):529–537. doi: 10.1259/0007-1285-46-547-529. [DOI] [PubMed] [Google Scholar]
- Withers H. R., Elkind M. M. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol Relat Stud Phys Chem Med. 1970;17(3):261–267. doi: 10.1080/09553007014550291. [DOI] [PubMed] [Google Scholar]