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. 1979 Oct;40(4):608–614. doi: 10.1038/bjc.1979.226

Bovine ocular squamous-cell carcinoma: lymphocyte response to phytohaemagglutinin and tumour antigen.

P A Jennings, M F Lavin, D J Hughes, P B Spradbrow
PMCID: PMC2010090  PMID: 497111

Abstract

The presence of ocular squamous-cell carcinomas in cattle was associated with significantly lower blastogenic response of peripheral-blood cultures to PHA than that of age-matched control cattle. The difference in blastogenic response was more marked when the external diameter of the tumour exceeded 2 cm. Cattle with aquamous-cell carcinomas had cell-mediated immunity against tumour extracts, as measured by the leucocyte adherence inhibition (LAI) microassay. The LAI reaction against tumour extracts was directly proportional to the general level of cell-mediated immunity as demonstrated by the lymphoproliferative response to PHA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON D. E. GENETIC ASPECTS OF CANCER WITH SPECIAL REFERENCE TO CANCER OF THE EYE IN THE BOVINE. Ann N Y Acad Sci. 1963 Nov 4;108:948–962. doi: 10.1111/j.1749-6632.1963.tb13432.x. [DOI] [PubMed] [Google Scholar]
  2. Baldwin R. W., Price M. R. Tumor antigens and tumor-host relationships. Annu Rev Med. 1976;27:151–163. doi: 10.1146/annurev.me.27.020176.001055. [DOI] [PubMed] [Google Scholar]
  3. Bowen J. G., Robins R. A., Baldwin R. W. Serum factors modifying cell mediated immunity to rat hepatoma d23 correlated with tumour growth. Int J Cancer. 1975 Apr 15;15(4):640–650. doi: 10.1002/ijc.2910150413. [DOI] [PubMed] [Google Scholar]
  4. Burdick J. F., Wells S. A., Jr, Herberman R. B. Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions. Surg Gynecol Obstet. 1975 Nov;141(5):779–794. [PubMed] [Google Scholar]
  5. DeLustro F., Argyris B. F. Mechanism of mastocytoma-mediated suppression of lymphocyte reactivity. J Immunol. 1976 Dec;117(6):2073–2080. [PubMed] [Google Scholar]
  6. Grosser N., Thompson D. M. Tube leukocyte (monocyte) adherence inhibition assay for the detection of anti-tumour immunity. III. "Blockade" of monocyte reactivity by excess free antigen and immune complexes in advanced cancer patients. Int J Cancer. 1976 Jul 15;18(1):58–66. doi: 10.1002/ijc.2910180109. [DOI] [PubMed] [Google Scholar]
  7. Halliday W. J., Maluish A. E., Little J. H., Davis N. C. Leukocyte adherence inhibition and specific immunoreactivity in malignant melanoma. Int J Cancer. 1975 Oct 15;16(4):645–658. doi: 10.1002/ijc.2910160415. [DOI] [PubMed] [Google Scholar]
  8. Halliday W. J., Maluish A. E., Stephenson P. M., Davis N. C. An evaluation of leukocyte adherence inhibition in the immunodiagnosis of colorectal cancer. Cancer Res. 1977 Jul;37(7 Pt 1):1962–1971. [PubMed] [Google Scholar]
  9. Lavin M. F., Kidson C. Repair of ionizing radiation induced DNA damage in human lymphocytes. Nucleic Acids Res. 1977 Nov;4(11):4015–4022. doi: 10.1093/nar/4.11.4015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Leveson S. H., Howell J. H., Paolini N. S., Tan M. H., Holyoke E. D., Goldrosen M. H. Correlations between the leukocyte adherence inhibition microassay and in vivo tests of transplantation resistance. Cancer Res. 1979 Feb;39(2 Pt 2):582–586. [PubMed] [Google Scholar]
  11. Lindsay G. C., 3rd, Heck F. C., England R. B. Ocular squamous cell carcinoma: immunological responses to tumour tissue and phytomitogens. Res Vet Sci. 1978 Jan;24(1):113–117. [PubMed] [Google Scholar]
  12. Maluish A. E. Experiences with leukocyte adherence inhibition in human cancer. Cancer Res. 1979 Feb;39(2 Pt 2):644–648. [PubMed] [Google Scholar]
  13. Maluish A. E., Halliday W. J. Quantitation of anti-tumor cell-mediated immunity by a lymphokine-dependent reaction using small volumes of blood. Cell Immunol. 1975 May;17(1):131–140. doi: 10.1016/s0008-8749(75)80013-x. [DOI] [PubMed] [Google Scholar]
  14. Naik S. N., Randelia H. P. Carcinoma of the eye in Indian cattle: an epidemiological aspect. Indian J Cancer. 1975 Sep;12(3):310–318. [PubMed] [Google Scholar]
  15. Phillips B., Roitt I. M. Evidence for transformation of human B lymphocytes by PHA. Nat New Biol. 1973 Feb 21;241(112):254–256. doi: 10.1038/newbio241254a0. [DOI] [PubMed] [Google Scholar]
  16. Priester W. A., Mantel N. Occurrence of tumors in domestic animals. Data from 12 United States and Canadian colleges of veterinary medicine. J Natl Cancer Inst. 1971 Dec;47(6):1333–1344. [PubMed] [Google Scholar]
  17. Spradbrow P. B., Wilson B. E., Hoffmann D., Kelly W. R., Francis J. Immunotherapy of bovine ocular squamous cell carcinomas. Vet Rec. 1977 Apr 30;100(18):376–378. doi: 10.1136/vr.100.18.376. [DOI] [PubMed] [Google Scholar]
  18. Tataryn D. N., MacFarlane J. K., Thomson D. M. Leucocyte adherence inhibition for detecting specific tumour immunity in early pancreatic cancer. Lancet. 1978 May 13;1(8072):1020–1022. doi: 10.1016/s0140-6736(78)90742-0. [DOI] [PubMed] [Google Scholar]
  19. Wardley R. An improved E rosetting technique for cattle. Br Vet J. 1977 Jul-Aug;133(4):432–434. doi: 10.1016/s0007-1935(17)34047-2. [DOI] [PubMed] [Google Scholar]
  20. Zembala M., Mytar B., Popiela T., Asherson G. L. Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: the role of suppressor cells. Int J Cancer. 1977 May 15;19(5):605–613. doi: 10.1002/ijc.2910190503. [DOI] [PubMed] [Google Scholar]

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