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. 1979 Nov;40(5):750–754. doi: 10.1038/bjc.1979.256

Levels of adenosine deaminase in some experimental animal tumours and the possible therapeutic effect of the ADA inhibitor 2-deoxy-coformycin.

J G Hall, L Gyure, J Peppard, E Orlans
PMCID: PMC2010098  PMID: 508578

Abstract

The intracellular adenosine deaminase activities (ADA) in 12 different experimental animal tumours were measured. Unlike the leukaemic lymphoblasts of man, those of two spontaneous rat leukaemias did not have elevated levels of the enzyme. Very high levels were found in a rat plasma-cell tumour (IR 461) and an attempt was made to treat such tumours with the specific enzyme inhibitor, 2-deoxy-coformycin. The shortage of this drug prevented a systematic study, but a daily dose of 8 mg/kg had a significant inhibitory effect on the growth of tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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