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. 1979 Nov;40(5):791–797. doi: 10.1038/bjc.1979.262

Synthesis and secretion of albumin in rats during treatment with a carcinogenic dose of N-2-acetylaminofluorene.

M M Harson, D J Williams
PMCID: PMC2010110  PMID: 508581

Abstract

The chronic administration of N-2-acetylaminofluorene (N-2-AAF) to rats causes a loss of hepatic cytoplasmic RNA, particularly from the endoplasmic-membrane fractions. At the end of the complete carcinogenic dose, the level of amino-acid incorporation into proalbumin is normal, despite the loss of 35% of membrane-bound RNA. The secretion of albumin, however, is inhibited. This inhibition of secretion is apparently the result of a change in membrane flow and differentiation; transfer of nascent protein from smooth-surfaced vesicles to the Golgi apparatus is blocked. The significance of these findings is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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