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. 1979 Nov;40(5):743–749. doi: 10.1038/bjc.1979.255

Influence of biogenic amines on the growth of xenografted human colorectal carcinomas.

P J Tutton, G G Steel
PMCID: PMC2010112  PMID: 41563

Abstract

The influence of some biogenic amines and amine-receptor-blocking drugs in the growth rate of human colorectal carcinomas propagated as s.c. xenografts in immune-deprived mice was studied. In mice treated with adrenaline, a beta-adrenergic agonist, the growth of xenografts was suppressed for 2 days, after which growth was resumed at a rate similar to that in control animals. Treatment with the phosphodiesterase inhibitor theophylline prolonged the adrenaline-induced inhibition of growth. Treatment with the beta-adrenergic antagonist sotalol or practolol increased the rate of tumour growth. Treatment with either serotonin or the histamine H2-receptor agonist Dimiprit had no effect on tumour growth rate. However, the antiserotoninergic drug BW 501C and the histamine H2-receptor antagonist cimetidine each caused short-term suppression of tumour growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appleman M. M., Terasaki W. L. Regulation of cyclic nucleotide phosphodiesterase. Adv Cyclic Nucleotide Res. 1975;5:153–162. [PubMed] [Google Scholar]
  2. Barsoum G. S., Gaddum J. H. The pharmacological estimation of adenosine and histamine in blood. J Physiol. 1935 Aug 22;85(1):1–14. doi: 10.1113/jphysiol.1935.sp003298. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bernlohr R. W., Haddox M. K., Goldberg N. D. Cyclic guanosine 3':5'-monophosphate in Escherichia coli and Bacillus lichenformis. J Biol Chem. 1974 Jul 10;249(13):4329–4331. [PubMed] [Google Scholar]
  4. Bullough W. S., Laurence E. B. Accelerating and decelerating actions of adrenalin on epidermal mitotic activity. Nature. 1966 May 14;210(5037):715–716. doi: 10.1038/210715a0. [DOI] [PubMed] [Google Scholar]
  5. Byron J. W. Evidence for a -adrenergic receptor initiating DNA synthesis in haemopoietic stem cells. Exp Cell Res. 1972 Mar;71(1):228–232. doi: 10.1016/0014-4827(72)90283-2. [DOI] [PubMed] [Google Scholar]
  6. Byron J. W. Manipulation of the cell cycle of the hemopoietic stem cell. Exp Hematol. 1975 Jan;3(1):44–53. [PubMed] [Google Scholar]
  7. Byron J. W. Mechanism for histamine H2-receptor induced cell-cycle changes in the bone marrow stem cell. Agents Actions. 1977 Jul;7(2):209–213. doi: 10.1007/BF01969974. [DOI] [PubMed] [Google Scholar]
  8. Hadden J. W., Hadden E. M., Middleton E., Jr Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes. Cell Immunol. 1970 Dec;1(6):583–595. doi: 10.1016/0008-8749(70)90024-9. [DOI] [PubMed] [Google Scholar]
  9. Hunt H., Tutton P. J. Adrenergic factors influencing the mitotic rate in stratified squamous epithelium of the buccal mucosa of the rat. Clin Exp Pharmacol Physiol. 1976 May-Jun;3(3):207–215. doi: 10.1111/j.1440-1681.1976.tb02666.x. [DOI] [PubMed] [Google Scholar]
  10. Klein R. M. Alteration of cellular proliferation in the ileal epithelium of suckling and weaned rats: the effects of isoproterenol. Cell Tissue Kinet. 1977 Jul;10(4):353–364. doi: 10.1111/j.1365-2184.1977.tb00303.x. [DOI] [PubMed] [Google Scholar]
  11. Kurland J. I., Hadden J. W., Moore M. A. Role of cyclic nucleotides in the proliferation of committed granulocyte-macrophage progenitor cells. Cancer Res. 1977 Dec;37(12):4534–4538. [PubMed] [Google Scholar]
  12. Leeson S. J., Voaden M. J. A chalone in the mammalian lens. II. Relative effects of adrenaline and noradrenaline on cell division in the rabbit lens. Exp Eye Res. 1970 Jan;9(1):67–72. doi: 10.1016/s0014-4835(70)80059-8. [DOI] [PubMed] [Google Scholar]
  13. Limbird L. E., Meyts P. D., Lefkowitz R. J. Beta-adrenergic receptors: evidence for negative cooperativity. Biochem Biophys Res Commun. 1975 Jun 16;64(4):1160–1168. doi: 10.1016/0006-291x(75)90815-3. [DOI] [PubMed] [Google Scholar]
  14. Lin C. S., Hurwitz L., Jenne J., Avner B. P. Mechanism of isoproterenol-induced desensitization of tracheal smooth muscle. J Pharmacol Exp Ther. 1977 Oct;203(1):12–22. [PubMed] [Google Scholar]
  15. Mickey J., Tate R., Lefkowitz R. J. Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro. J Biol Chem. 1975 Jul 25;250(14):5727–5729. [PubMed] [Google Scholar]
  16. Mukherjee C., Caron M. G., Lefkowitz R. J. Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. Proc Natl Acad Sci U S A. 1975 May;72(5):1945–1949. doi: 10.1073/pnas.72.5.1945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Nowak K., Peckham M. J., Steel G. G. Variation in response of xenografts of colo-rectal carcinoma to chemotherapy. Br J Cancer. 1978 Apr;37(4):576–584. doi: 10.1038/bjc.1978.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Steel G. G., Courtenay V. D., Rostom A. Y. Improved immune-suppression techniques for the exongrafting of human tumours. Br J Cancer. 1978 Feb;37(2):224–230. doi: 10.1038/bjc.1978.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tutton P. J., Barkla D. H. Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata. Cell Biol Int Rep. 1978 Mar;2(2):199–202. doi: 10.1016/0309-1651(78)90043-7. [DOI] [PubMed] [Google Scholar]
  20. Tutton P. J., Barkla D. H. The influence of serotonin on the mitotic rate in the colonic crypt epithelium and in colonic adenocarcinoma in rats. Clin Exp Pharmacol Physiol. 1978 Jan-Feb;5(1):91–94. doi: 10.1111/j.1440-1681.1978.tb00657.x. [DOI] [PubMed] [Google Scholar]
  21. Tutton P. J., Helme R. D. The influence of adrenoreceptor activity on crypt cell proliferation in the rat jejunum. Cell Tissue Kinet. 1974 Mar;7(2):125–136. doi: 10.1111/j.1365-2184.1974.tb00405.x. [DOI] [PubMed] [Google Scholar]
  22. Tutton P. J. The influence of histamine on epithelial cell proliferation in the jejunum of the rat. Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):369–373. doi: 10.1111/j.1440-1681.1976.tb00613.x. [DOI] [PubMed] [Google Scholar]

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