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. 1979 Dec;40(6):903–913. doi: 10.1038/bjc.1979.284

Induction of myeloid leukaemia by whole-body single exposure of CBA male mice to x-rays.

I R Major
PMCID: PMC2010144  PMID: 294292

Abstract

A curvilinear dose response of myeloid leukaemia induction in the CBA male mouse was obtained after single whole-body X-irradiation at about 3 months of age. This strain has a very low spontaneous incidence of the disease and no cases were found in the unirradiated controls. The incidence was independent of dose rate over the range used (4.2-552 rad/min). Diagnosis required histopathological examination of various body tissues, the gross anatomical changes being easily confused with other haemopoietic disorders, but a few cases were recognized in life from blood samples. Curve-fitting to various models based on theories of radiocarcinogenic mechanism is described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albert R. E., Burns F. J., Heimbach R. D. Skin damage and tumor formation from grid and sieve patterns of electron and beta radiation in the rat. Radiat Res. 1967 Mar;30(3):525–540. [PubMed] [Google Scholar]
  2. Albert R. E., Burns F. J., Heimbach R. D. The effect of penetration depth of electron radiation on skin tumor formation in the rat. Radiat Res. 1967 Mar;30(3):515–524. [PubMed] [Google Scholar]
  3. BOND V. P., CRONKITE E. P., LIPPINCOTT S. W., SHELLABARGER C. J. Studies on radiation-induced mammary gland neoplasia in the rat. III. Relation of the neoplastic response to dose of total-body radiation. Radiat Res. 1960 Mar;12:276–285. [PubMed] [Google Scholar]
  4. CRONKITE E. P., MOLONEY W., BOND V. P. Radiation leukemogenesis: an analysis of the problem. Am J Med. 1960 May;28:673–682. doi: 10.1016/0002-9343(60)90126-1. [DOI] [PubMed] [Google Scholar]
  5. ELKIND M. M., SUTTON H. Radiation response of mammalian cells grown in culture. 1. Repair of X-ray damage in surviving Chinese hamster cells. Radiat Res. 1960 Oct;13:556–593. [PubMed] [Google Scholar]
  6. Hendry J. H. Differential split-dose radiation response of resting and regenerating haemopoietic stem cells. Int J Radiat Biol Relat Stud Phys Chem Med. 1973 Nov;24(5):469–473. doi: 10.1080/09553007314551351. [DOI] [PubMed] [Google Scholar]
  7. Hulse E. V. Incidence and pathogenesis of skin tumours in mice irradiated with single external doses of low energy beta particles. Br J Cancer. 1967 Sep;21(3):531–547. doi: 10.1038/bjc.1967.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hulse E. V., Mole R. H., Papworth D. G. Radiosensitivities of cells from which radiation-induced skin tumours are derived. Int J Radiat Biol Relat Stud Phys Chem Med. 1968;14(5):437–444. doi: 10.1080/09553006814551321. [DOI] [PubMed] [Google Scholar]
  9. Ishimaru T., Hoshino T., Ichimaru M., Okada H., Tomiyasu T. Leukemia in atomic bomb survivors, Hiroshima and Nagasaki, 1 October 1950--30 September 1966. Radiat Res. 1971 Jan;45(1):216–233. [PubMed] [Google Scholar]
  10. MOLE R. H. The development of leukaemia in irradiated animals. Br Med Bull. 1958 May;14(2):174–177. doi: 10.1093/oxfordjournals.bmb.a069664. [DOI] [PubMed] [Google Scholar]
  11. Major I. R., Mole R. H. Myeloid leukaemia in x-ray irradiated CBA mice. Nature. 1978 Mar 30;272(5652):455–456. doi: 10.1038/272455a0. [DOI] [PubMed] [Google Scholar]
  12. Modan B., Lubin E. Radiation induced leukemia in man. Ser Haematol. 1974;7(2):192–210. [PubMed] [Google Scholar]
  13. Mole R. H. Ionizing radiation as a carcinogen: practical questions and academic pursuits The Silvanus Thompson Memorial Lecture delivered at The British Institute of Radiology on April 18, 1974. Br J Radiol. 1975 Mar;48(567):157–169. doi: 10.1259/0007-1285-48-567-157. [DOI] [PubMed] [Google Scholar]
  14. Paasikallio K., Spring E., Salmo M. Experiments on radiation-induced tumor. Theoretical view-points. Acta Radiol Ther Phys Biol. 1976 Aug;15(4):357–368. doi: 10.3109/02841867609131973. [DOI] [PubMed] [Google Scholar]
  15. Shellabarger C. J., Schmidt R. W. Mammary neoplasia in the rat as related to dose of partial-body irradiation. Radiat Res. 1967 Mar;30(3):497–506. [PubMed] [Google Scholar]
  16. Stewart A. M., Kneale G. W. Age-distribution of cancers caused by obstetric x-rays and their relevance to cancer latent periods. Lancet. 1970 Jul 4;2(7662):4–8. doi: 10.1016/s0140-6736(70)92472-4. [DOI] [PubMed] [Google Scholar]
  17. UPTON A. C., WOLFF F. F., FURTH J., KIMBALL A. W. A comparison of the induction of myeloid and lymphoid leukemias in x-radiated RF mice. Cancer Res. 1958 Aug;18(7):842–848. [PubMed] [Google Scholar]
  18. Yuhas J. M., Walker A. E. Exposure-response curve for radiation-induced lung tumors in the mouse. Radiat Res. 1973 May;54(2):261–273. [PubMed] [Google Scholar]

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