Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1980 Jan;41(1):47–51. doi: 10.1038/bjc.1980.6

Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth.

P J Tutton, D H Barkla
PMCID: PMC2010170  PMID: 7362778

Abstract

The influence of two prostaglandin (PG) analogues, 16,16-dimethyl PG E2 and 16,16-dimethyl PG F2 alpha and of the cyclo-oxygenase inhibitor, flurbiprofen, on epithelial cell proliferation was assessed using a stathmokinetic technique. The epithelia examined were those of the jejunal crypts, the colonic crypts and that of dimethylhydrazine-induced adenocarcinomas of rat colon. The influence of the two prostaglandin analogues, and of flurbiprofen, on the growth of a human colorectal tumour propagated as xenografts in immune-deprived mice was also assessed. The PG E2 analogue transiently inhibited xenograft growth, but was without effect on the mitotic rate in the rat tissues. The PG F2 alpha analogue was also found to inhibit xenograft growth but, unlike the PG E2 analogue, it was found to be a strong inhibitor of cell proliferation in rat colonic tumours, and an accelerator of proliferation in jejunal-crypt cells. The only statistically significant effect of flurbiprofen was to accelerate cell division in the rat colonic tumours.

Full text

PDF
47

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Courtenay V. D., Mills J. An in vitro colony assay for human tumours grown in immune-suppressed mice and treated in vivo with cytotoxic agents. Br J Cancer. 1978 Feb;37(2):261–268. doi: 10.1038/bjc.1978.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Crook D., Collins A. ,. Prostaglandin synthetase activity from human rheumatoid synovial tissue and its inhibition by non-steroidal anti-inflammatory drugs. Prostaglandins. 1975 Jun;9(6):857–865. doi: 10.1016/0090-6980(75)90074-x. [DOI] [PubMed] [Google Scholar]
  3. Druckrey H., Preussmann R., Matzkies F., Ivankovic S. Selektive Erzeugung von Darmkrebs bei Ratten durch 1,2-Dimethyl-hydrazin. Naturwissenschaften. 1967 Jun;54(11):285–286. doi: 10.1007/BF00620890. [DOI] [PubMed] [Google Scholar]
  4. Kadowitz P. J., Sweet C. S., Brody M. J. Enhancement of sympathetic neurotransmission by prostaglandin F 2 in the cutaneous vascular bed of the dog. Eur J Pharmacol. 1972 May;18(2):189–194. doi: 10.1016/0014-2999(72)90241-5. [DOI] [PubMed] [Google Scholar]
  5. Kuehl F. A., Jr, Humes J. L., Tarnoff J., Cirillo V. J., Ham E. A. Prostaglandin receptor site: evidence for an essential role in the action of luteinizing hormone. Science. 1970 Aug 28;169(3948):883–886. doi: 10.1126/science.169.3948.883. [DOI] [PubMed] [Google Scholar]
  6. Kurland J., Moore M. A. Modulation of hemopoiesis by prostaglandins. Exp Hematol. 1977 Sep;5(5):357–373. [PubMed] [Google Scholar]
  7. Naseem S. M., Hollander V. P. Insulin reversal of growth inhibition of plasma cell tumor by prostaglandin or adenosine 3',5'-monophosphate. Cancer Res. 1973 Nov;33(11):2909–2912. [PubMed] [Google Scholar]
  8. Nowak K., Peckham M. J., Steel G. G. Variation in response of xenografts of colo-rectal carcinoma to chemotherapy. Br J Cancer. 1978 Apr;37(4):576–584. doi: 10.1038/bjc.1978.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Santoro M. G., Philpott G. W., Jaffe B. M. Dose dependent inhibition of B-16 melanoma growth in vivo by a synthetic analogue of PGE2. Prostaglandins. 1977 Oct;14(4):645–651. doi: 10.1016/0090-6980(77)90191-5. [DOI] [PubMed] [Google Scholar]
  10. Schultz G., Schultz K., Hardman J. G. Effects of norepinephrine on cyclic nucleotide levels in the ductus deferens of the rat. Metabolism. 1975 Mar;24(3):429–437. doi: 10.1016/0026-0495(75)90122-5. [DOI] [PubMed] [Google Scholar]
  11. Tutton P. J., Barkla D. H. Cell proliferation in the descending colon of dimethylhydrazine treated rats and in dimethylhydrazine induced adenocarcinomata. Virchows Arch B Cell Pathol. 1976 Aug 11;21(2):147–160. doi: 10.1007/BF02899151. [DOI] [PubMed] [Google Scholar]
  12. Tutton P. J., Barkla D. H. Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata. Cell Biol Int Rep. 1978 Mar;2(2):199–202. doi: 10.1016/0309-1651(78)90043-7. [DOI] [PubMed] [Google Scholar]
  13. Tutton P. J., Barkla D. H. The influence of adrenoceptor activity on cell proliferation in colonic crypt ipithelium and in colonic adenocarcinomata. Virchows Arch B Cell Pathol. 1977 Jun 24;24(2):139–146. doi: 10.1007/BF02889274. [DOI] [PubMed] [Google Scholar]
  14. Tutton P. J., Helme R. D. The influence of adrenoreceptor activity on crypt cell proliferation in the rat jejunum. Cell Tissue Kinet. 1974 Mar;7(2):125–136. doi: 10.1111/j.1365-2184.1974.tb00405.x. [DOI] [PubMed] [Google Scholar]
  15. Tutton P. J. Neural and endocrine control systems acting on the population kinetics of the intestinal epithelium. Med Biol. 1977 Aug;55(4):201–208. [PubMed] [Google Scholar]
  16. Tutton P. J., Steel G. G. Influence of biogenic amines on the growth of xenografted human colorectal carcinomas. Br J Cancer. 1979 Nov;40(5):743–749. doi: 10.1038/bjc.1979.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tutton P. J. The influence of histamine on epithelial cell proliferation in the jejunum of the rat. Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):369–373. doi: 10.1111/j.1440-1681.1976.tb00613.x. [DOI] [PubMed] [Google Scholar]
  18. Whittaker N., Bunting S., Salmon J., Moncada S., Vane J. R., Johnson R. A., Morton D. R., Kinner J. H., Gorman R. R., McGuire J. C. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins. 1976 Dec;12(6):915–928. doi: 10.1016/0090-6980(76)90126-x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES