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. 1980 Jan;41(1):33–39. doi: 10.1038/bjc.1980.4

Malignant myelomonocytic cells after in vitro infection of marrow cells with Friend leukaemia virus.

N G Testa, T M Dexter, D Scott, N M Teich
PMCID: PMC2010174  PMID: 6928787

Abstract

Infection of long-term BDF1 marrow cultures with Friend leukaemia virus complex (FLV) induced transformed cells with myelomonocytic characteristics, which were isolated only 14 days after the viral infection. Criteria for transformation were growth in suspension cultures and high plating efficiency in agar. The lymphatic leukaemia virus (LLV) replicates in these suspension cultures, but the spleen focus-forming virus (SFFV) component of the FLV complex has not been detected. Injection of the transformed cells into syngeneic neonatal or adult mice leads to the development of leukaemia which can be demonstrated to be of donor origin by the presence of two metacentric marker chromosomes which are also seen in the cultured cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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