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. 1980 Mar;41(3):454–468. doi: 10.1038/bjc.1980.70

Inter-species comparisons of carcinogenicity.

I F Purchase
PMCID: PMC2010223  PMID: 7387835

Abstract

The carcinogenicity of 250 chemicals in 2 species, usually the rat and the mouse, was obtained from the published literature through 3 independent sources. Of the 250 compounds listed, 38% were non-carcinogenic in both rats and mice, and 44% were carcinogenic in both species. A total of 43 compounds had different results in the two species, 21 (8%) being carcinogenic in mice only, 17 (7%) in rats only and 5 (2%) having differing results from other species. A comparison of the major target organs affected by chemicals carcinogenic in both species revealed that 64% of the chemicals studied produced cancer at the same site. This comparison of carcinogenic activity in 2 species suggests that extrapolation from results in a single-animal study to man may be subject to substantial errors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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