Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1980 Mar;41(3):415–421. doi: 10.1038/bjc.1980.65

Malignancy grading in squamous carcinoma of uterine cervix treated by surgery.

C A Pagnini, P Della Palma, G De Laurentiis
PMCID: PMC2010224  PMID: 7387831

Abstract

Some morphological patterns (histological type, vascular invasion, depth of invasion, lymphocytic infiltrate, mode of spread, necrosis) in 125 cases of squamous cervical carcinoma treated by surgery were analysed and graded in order to identify a histoprognostic score. Clinical data on F.I.G.O. stage, modality of surgical treatment, age, hormonal state (pre- or post-menopause) and 5-year survival were known for each patient. Two groups (low and high malignancy) were disclosed, and the difference of survival rate between the 2 was highly significant (P less than 0.001).

Full text

PDF
415

Images in this article

416Fig. 1
on p.416
416Fig. 2
on p.416
417Fig. 3
on p.417
417Fig. 4
on p.417

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FRIEDELL G. H., PARSONS L. Blood vessel invasion in cancer of the cervix. Cancer. 1962 Nov-Dec;15:1269–1274. doi: 10.1002/1097-0142(196211/12)15:6<1269::aid-cncr2820150624>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  2. Finck F. M., Denk M. Cervical carcinoma: relationship between histology and survival following radiation therapy. Obstet Gynecol. 1970 Mar;35(3):339–343. [PubMed] [Google Scholar]
  3. Fisher E. R., Palekar A. S., Gregorio R. M., Redmond C., Fisher B. Pathological findings from the national surgical adjuvant breast project (Protocol No. 4). IV. Significance of tumor necrosis. Hum Pathol. 1978 Sep;9(5):523–530. doi: 10.1016/s0046-8177(78)80133-6. [DOI] [PubMed] [Google Scholar]
  4. Friedell G. H., Steiner G., Kistner R. W. Prognostic value of blood-vessel invasion in cervical cancer. Obstet Gynecol. 1967 Jun;29(6):855–857. [PubMed] [Google Scholar]
  5. Gunderson L. L., Weems W. S., Herbertson R. M., Plenk H. P. Correlation of histopathology with clinical results following radiation therapy for carcinoma of the cervix. Am J Roentgenol Radium Ther Nucl Med. 1974 Jan;120(1):74–87. doi: 10.2214/ajr.120.1.74. [DOI] [PubMed] [Google Scholar]
  6. Gusberg S. B., Herman G. G. Radiosensitivity and virulence factors in cervical cancer. Individualization of treatment. Am J Obstet Gynecol. 1968 Mar 1;100(5):627–639. doi: 10.1016/s0002-9378(15)33388-3. [DOI] [PubMed] [Google Scholar]
  7. Gusberg S. B., Yannopoulos K., Cohen C. J. Virulence indices and lymph nodes in cancer of the cervix. Am J Roentgenol Radium Ther Nucl Med. 1971 Feb;111(2):273–277. doi: 10.2214/ajr.111.2.273. [DOI] [PubMed] [Google Scholar]
  8. MITANI Y., FUJII J. I., MIYAMURA M., ISHIZUSI, MATSUKADO M. Lymph node metastases of carcinoma of the uterine cervix. Am J Obstet Gynecol. 1962 Aug 15;84:515–522. doi: 10.1016/s0002-9378(16)35701-5. [DOI] [PubMed] [Google Scholar]
  9. Ng A. B., Atkin N. B. Histological cell type and DNA value in the prognosis of squamous cell cancer of uterine cervix. Br J Cancer. 1973 Oct;28(4):322–331. doi: 10.1038/bjc.1973.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reagan J. W., Ng A. B., Wentz W. B. Concepts of genesis and development in early cervical neoplasia. Obstet Gynecol Surv. 1969 Jul;24(7 Pt 2):860–874. doi: 10.1097/00006254-196907001-00016. [DOI] [PubMed] [Google Scholar]
  11. Sidhu G. S., Koss L. G., Barber R. K. Relation of histologic factors to the response of stage I epidermoid carcinoma of the cervix to surgical treatment. Analysis of 115 patients. Obstet Gynecol. 1970 Mar;35(3):329–338. [PubMed] [Google Scholar]
  12. Swan D. S., Roddick J. W. A clinical-pathological correlation of cell type classification for cervical cancer. Am J Obstet Gynecol. 1973 Jul 1;116(5):666–670. doi: 10.1016/s0002-9378(15)33132-x. [DOI] [PubMed] [Google Scholar]
  13. Van Nagell J. R., Jr, Donaldson E. S., Wood E. G., Maruyama Y., Utley J. Small cell cancer of the uterine cervix. Cancer. 1977 Nov;40(5):2243–2249. doi: 10.1002/1097-0142(197711)40:5<2243::aid-cncr2820400534>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  14. WENTZ W. B. Histologic grade and survival in cervical cancer. Obstet Gynecol. 1961 Oct;18:412–416. [PubMed] [Google Scholar]
  15. WENTZ W. B., LEWIS G. C., Jr CORRELATION OF HISTOLOGIC MORPHOLOGY AND SURVIVAL IN CERVICAL CANCER FOLLOWING RADIATION THERAPY. Obstet Gynecol. 1965 Aug;26:228–232. [PubMed] [Google Scholar]
  16. WENTZ W. B., REAGAN J. W. Survival in cervical cancer with respect to cell type. Cancer. 1959 Mar-Apr;12(2):384–388. doi: 10.1002/1097-0142(195903/04)12:2<384::aid-cncr2820120222>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  17. van Nagell J. R., Jr, Donaldson E. S., Wood E. G., Parker J. C., Jr The significance of vascular invasion and lymphocytic infiltration in invasive cervical cancer. Cancer. 1978 Jan;41(1):228–234. doi: 10.1002/1097-0142(197801)41:1<228::aid-cncr2820410131>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES