Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1980 Mar;41(3):356–359. doi: 10.1038/bjc.1980.58

Electron spin resonance studies on caeruloplasmin and iron transferrin in patients with chronic lymphocytic leukaemia.

J A Green, T Pocklington, A A Dawson, M Foster
PMCID: PMC2010244  PMID: 6248093

Abstract

Whole-blood caeruloplasmin measured by electron spin resonance was studied in 41 patients with chronic lymphocytic leukaemia. The levels were above normal at all stages of the disease, rose with increasing clinical involvement, and were higher in progressive than inactive disease. Whole-blood iron transferrin levels were more variable, and were significantly raised only in patients with marrow failure.

Full text

PDF
356

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews G. S. Studies of plasma zinc, copper, caeruloplasmin, and growth hormone: with special reference to carcinoma of the bronchus. J Clin Pathol. 1979 Apr;32(4):325–333. doi: 10.1136/jcp.32.4.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Beamish M. R., Jones P. A., Trevett D., Evans I. H., Jacobs A. Iron metabolism in Hodgkin's disease. Br J Cancer. 1972 Dec;26(6):444–452. doi: 10.1038/bjc.1972.61. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fisher G. L., Shifrine M. Hypothesis for the mechanism of elevated serum copper in cancer patients. Oncology. 1978;35(1):22–25. doi: 10.1159/000225249. [DOI] [PubMed] [Google Scholar]
  4. Foster M. A., Pocklington T., Miller J. D., Mallard J. R. A study of electron spin resonance spectra of whole blood from normal and tumour bearing patients. Br J Cancer. 1973 Oct;28(4):340–348. doi: 10.1038/bjc.1973.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Foster M., Dawson A., Pockington T., Fell L. Electron spin resonance measurements of blood caeruloplasmin and iron transferrin levels in patients with non-Hodgkin's lymphoma. Clin Radiol. 1977 Jan;28(1):23–28. doi: 10.1016/s0009-9260(77)80131-1. [DOI] [PubMed] [Google Scholar]
  6. Frieden E. The ferrous to ferric cycles in iron metabolism. Nutr Rev. 1973 Feb;31(2):41–44. doi: 10.1111/j.1753-4887.1973.tb05977.x. [DOI] [PubMed] [Google Scholar]
  7. Hrgovcic M., Tessmer C. F., Minckler T. M., Mosier B., Taylor G. H. Serum copper levels in lymphoma and leukemia. Special reference to Hodgkin's disease. Cancer. 1968 Apr;21(4):743–755. doi: 10.1002/1097-0142(196804)21:4<743::aid-cncr2820210427>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  8. Hrgovcic M., Tessmer C. F., Thomas F. B., Fuller L. M., Gamble J. F., Shullenberger C. C. Significance of serum copper levels in adult patients with Hodgkin's disease. Cancer. 1973 Jun;31(6):1337–1345. doi: 10.1002/1097-0142(197306)31:6<1337::aid-cncr2820310606>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  9. Jaffe N., Bishop J. M. The serum iron level, hematocrit, sedimentation rate, and leukocyte alkaline phosphatase level in pediatric patients with Hodgkin's disease. Cancer. 1970 Aug;26(2):332–337. doi: 10.1002/1097-0142(197008)26:2<332::aid-cncr2820260214>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  10. LAHEY M. E., GUBLER C. J., CARTWRIGHT G. E., WINTROBE M. M. Studies on copper metabolism. VII. Blood copper in pregnancy and various pathologic states. J Clin Invest. 1953 Apr;32(4):329–339. doi: 10.1172/JCI102743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MARKOWITZ H., GUBLER C. J., MAHONEY J. P., CARTWRIGHT G. E., WINTROBE M. M. Studies on copper metabolism. XIV. Copper, ceruloplasmin and oxidase activity in sera of normal human subjects, pregnant women, and patients with infection, hepatolenticular degeneration and the nephrotic syndrome. J Clin Invest. 1955 Oct;34(10):1498–1508. doi: 10.1172/JCI103201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pocklington T., Foster M. A. Electron spin resonance of caeruloplasmin and iron transferrin in blood of patients with various malignant diseases. Br J Cancer. 1977 Sep;36(3):369–374. doi: 10.1038/bjc.1977.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rai K. R., Sawitsky A., Cronkite E. P., Chanana A. D., Levy R. N., Pasternack B. S. Clinical staging of chronic lymphocytic leukemia. Blood. 1975 Aug;46(2):219–234. [PubMed] [Google Scholar]
  14. Ray G. R., Wolf P. H., Kaplan H. S. Value of laboratory indicators in Hodgkin's disease: preliminary results. Natl Cancer Inst Monogr. 1973 May;36:315–323. [PubMed] [Google Scholar]
  15. Tessmer C. F., Hrgovcic M., Brown B. W., Wilbur J., Thomas F. B. Serum copper correlations with bone marrow. Cancer. 1972 Jan;29(1):173–179. doi: 10.1002/1097-0142(197201)29:1<173::aid-cncr2820290127>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES