Abstract
The influence of human serum albumin (HA) on the biological effects of 13 chemotherapeutic agents was studied in vitro in the human leukaemia cell line MOLT-3. On the basis of changes in biological activity influenced by HA, these drugs may be divided into three types. Type I agents include cis-diamminedichloroplatinum (II), 4'-(9-acridinylamino)methanesulphon-m-anisidide, neocarzinostatin, nitrogen mustard, adriamycin, daunorubicin and mitomycin C--drugs whose biological activities are reduced in the presence of HA. The biological activities of Type II drugs (cytosine arabinoside, fluorouracil and actinomycin D) are not influenced by HA. The biological activities of Type III drugs (bleomycin, vincristine and vinblastine) are increased in the presence of HA. These results indicate that serum HA interferes in vitro with certain anticancer agents in terms of biological activity and, probably, clinical effectiveness. HA-drug interaction may be a major factor governing the pharmacology of Type I anticancer agents in man.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cysyk R. L., Shoemaker D., Adamson R. H. The pharmacologic disposition of 4'-(9-acridinylamino)methanesulfon-m-anisidide in mice and rats. Drug Metab Dispos. 1977 Nov-Dec;5(6):579–590. [PubMed] [Google Scholar]
- DeConti R. C., Toftness B. R., Lange R. C., Creasey W. A. Clinical and pharmacological studies with cis-diamminedichloroplatinum (II). Cancer Res. 1973 Jun;33(6):1310–1315. [PubMed] [Google Scholar]
- Dixon R. L., Adamson R. H. Antitumor activity and pharmacologic disposition of cytosine arabinoside (NSC-63878). Cancer Chemother Rep. 1965 Oct;48:11–16. [PubMed] [Google Scholar]
- Donigian D. W., Owellen R. J. Interaction of vinblastine, vincristine and colchicine with serum proteins. Biochem Pharmacol. 1973 Sep 1;22(17):2113–2119. doi: 10.1016/0006-2952(73)90110-x. [DOI] [PubMed] [Google Scholar]
- GOLDIN A., VENDITTI J. M., HUMPHREYS S. T., MANTEL N. Comparison of the relative effectiveness of folic acid congeners against advanced leukemia in mice. J Natl Cancer Inst. 1957 Dec;19(6):1133–1135. [PubMed] [Google Scholar]
- Koch-Weser J., Sellers E. M. Binding of drugs to serum albumin (first of two parts). N Engl J Med. 1976 Feb 5;294(6):311–316. doi: 10.1056/NEJM197602052940605. [DOI] [PubMed] [Google Scholar]
- LINFORD J. H. Some interactions of nitrogen mustards with constituents of human blood serum. Biochem Pharmacol. 1961 Dec;8:343–357. doi: 10.1016/0006-2952(61)90051-x. [DOI] [PubMed] [Google Scholar]
- LeRoy A. F., Lutz R. J., Dedrick R. L., Litterst C. L., Guarino A. M. Pharmacokinetic study of cis-dichlorodiammineplatinum(II) (DDP) in the beagle dog: thermodynamic and kinetic behavior of DDP in a biologic millieu. Cancer Treat Rep. 1979 Jan;63(1):59–71. [PubMed] [Google Scholar]
- Minowada J., Onuma T., Moore G. E. Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes. J Natl Cancer Inst. 1972 Sep;49(3):891–895. [PubMed] [Google Scholar]
- Ohnuma T., Nogeire C., Cuttner J., Holland J. F. Phase I study with neocarzinostatin: tolerance to two hour infusion and continuous infusion. Cancer. 1978 Oct;42(4):1670–1679. doi: 10.1002/1097-0142(197810)42:4<1670::aid-cncr2820420403>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- Sikic B. I., Collins J. M., Mimnaugh E. G., Gram T. E. Improved therapeutic index of bleomycin when administered by continuous infusion in mice. Cancer Treat Rep. 1978 Dec;62(12):2011–2017. [PubMed] [Google Scholar]
- Takahashi I., Ohnuma T., Holland J. F. A comparison of the biological effects of dichloromethotrexate and methotrexate on human leukemic cells in culture. Cancer Res. 1979 Apr;39(4):1264–1268. [PubMed] [Google Scholar]
- VOGEL A. W. Tumor and marrow damage occurring from methotrexate, monofluoromethotrexate, difluoromethotrexate, and dichloromethotrexate. Cancer Res. 1961 Jul;21:743–748. [PubMed] [Google Scholar]