Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1980 Jun;41(6):901–907. doi: 10.1038/bjc.1980.167

Cyclophosphamide-induced lung damage in mice: protection by a small preliminary dose.

C H Collis, C M Wilson, J M Jones
PMCID: PMC2010345  PMID: 7426315

Abstract

Cycylphosphamide (Cy) produces an interstitial pneumonitis in CBA mice. The extent of the lung damage has been quantified by measuring the increase in ventilation rate over 6 weeks after an i.p. injection of Cy 200, 250 and 300 mg/kg. A dose-dependent response was found. When a preliminary ("priming") dose of Cy at 50 mg/kg was given 7, 9 or 14 days before a single large dose of 250 mg/kg, lung damage was reduced, as shown by a smaller increase in ventilation rate than in those receiving 250 mg/kg alone, and this difference was significant (P less than 0.01) in the Day-14-and highly significant (P<0.001) in the Day-7-"primed" groups. When primed less than 7 days before, there was a relative increase in ventilation rate, which was statistically significant (P less than 0.01) in the Day-1-primed group. Similar effects were also seen in the survival of the mice.

Full text

PDF
901

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adamson I. Y., Bowden D. H. The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen. Lab Invest. 1974 Jan;30(1):35–42. [PubMed] [Google Scholar]
  2. André R., Rochant H., Dreyfus B., Duhamel G., Péchère J. C. Fibrose interstitielle diffuse du poumon au cours d'une maladie de Hodgkin traitée par des doses élevées d'endoxan. Bull Mem Soc Med Hop Paris. 1967 Nov 3;118(12):1133–1141. [PubMed] [Google Scholar]
  3. Blackett N. M., Aguado M. The enhancement of haemopoietic stem cell recovery in irradiated mice by prior treatment with cyclophosphamide. Cell Tissue Kinet. 1979 May;12(3):291–298. doi: 10.1111/j.1365-2184.1979.tb00151.x. [DOI] [PubMed] [Google Scholar]
  4. Carmel R. J., Brown J. M. The effect of cyclophosphamide and other drugs on the incidence of pulmonary metastases in mice. Cancer Res. 1977 Jan;37(1):145–151. [PubMed] [Google Scholar]
  5. Gould V. E., Miller J. Sclerosing alveolitis induced by cyclophosphamide. Ultrastructural observations on alveolar injury and repair. Am J Pathol. 1975 Dec;81(3):513–530. [PMC free article] [PubMed] [Google Scholar]
  6. Gregory S. A., Fried W., Knospe W. H., Trobaugh F. E., Jr Accelerated regeneration of transplanted hematopoietic stem cells in irradiated mice pretreated with cyclophosphamide. Blood. 1971 Feb;37(2):196–203. [PubMed] [Google Scholar]
  7. Mark G. J., Lehimgar-Zadeh A., Ragsdale B. D. Cyclophosphamide pneumonitis. Thorax. 1978 Feb;33(1):89–93. doi: 10.1136/thx.33.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Millar J. L., Hudspith B. N., Blackett N. M. Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan. Br J Cancer. 1975 Aug;32(2):193–198. doi: 10.1038/bjc.1975.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Millar J. L., Hudspith B. N. Sparing effect of cyclophosphamide (NSC-26271) pretreatment on animals lethally treated with gamma-irradiation. Cancer Treat Rep. 1976 Apr;60(4):409–414. [PubMed] [Google Scholar]
  10. O'Connell T. X., Berenbaum M. C. Cardiac and pulmonary effects of high doses of cyclophosphamide and isophosphamide. Cancer Res. 1974 Jul;34(7):1586–1591. [PubMed] [Google Scholar]
  11. Patel A. R., Shah P. C., Rhee H. L., Sassoon H., Rao K. P. Cyclophosphamide therapy and interstitial pulmonary fibrosis. Cancer. 1976 Oct;38(4):1542–1549. doi: 10.1002/1097-0142(197610)38:4<1542::aid-cncr2820380416>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  12. Phelps T. A., Blackett N. M. Protection of intestinal damage by pretreatment with cytarabine (cytosine arabinoside). Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1617–1620. doi: 10.1016/0360-3016(79)90784-3. [DOI] [PubMed] [Google Scholar]
  13. Phillips T. L., Fu K. K. Quantification of combined radiation therapy and chemotherapy effects on critical normal tissues. Cancer. 1976 Feb;37(2 Suppl):1186–1200. doi: 10.1002/1097-0142(197602)37:2+<1186::aid-cncr2820370830>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  14. Sostman H. D., Matthay R. A., Putman C. E. Cytotoxic drug-induced lung disease. Am J Med. 1977 Apr;62(4):608–615. doi: 10.1016/0002-9343(77)90424-7. [DOI] [PubMed] [Google Scholar]
  15. Steel G. G., Adams K. Enhancement by cytotoxic agents of artificial pulmonary metastasis. Br J Cancer. 1977 Dec;36(6):653–658. doi: 10.1038/bjc.1977.247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Steel G. G., Adams K., Peckham M. J. Lung damage in C57B1 mice following thoracic irradiation: enhancement by chemotherapy. Br J Radiol. 1979 Sep;52(621):741–747. doi: 10.1259/0007-1285-52-621-741. [DOI] [PubMed] [Google Scholar]
  17. Steel G. G., Peckham M. J. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys. 1979 Jan;5(1):85–91. doi: 10.1016/0360-3016(79)90044-0. [DOI] [PubMed] [Google Scholar]
  18. Travis E. L., Vojnovic B., Davies E. E., Hirst D. G. A plethysmographic method for measuring function in locally irradiated mouse lung. Br J Radiol. 1979 Jan;52(613):67–74. doi: 10.1259/0007-1285-52-613-67. [DOI] [PubMed] [Google Scholar]
  19. van Putten L. M., Kram L. K., van Dierendonck H. H., Smink T., Füzy M. Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection. Int J Cancer. 1975 Apr 15;15(4):588–595. doi: 10.1002/ijc.2910150408. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES